| Thu Sep 17 | 7:30 PM ET | Syracuse Orange at Pittsburgh Panthers | 13 - 27 | Acrisure Stadium |
| Fri Sep 18 | 7:30 PM ET | Miami Hurricanes vs Wake Forest Demon Deacons | — | L&N Federal Credit Union Stadium neutral |
| Fri Sep 18 | 8:00 PM ET | Houston Cougars vs Texas Tech Red Raiders | — | AT&T Stadium neutral |
| Fri Sep 18 | 10:30 PM ET | Portland State Vikings at Oregon Ducks | 0 - 84 | Autzen Stadium |
| Sat Sep 19 | 11:30 AM ET | Coastal Carolina Chanticleers at Delaware Blue Hens | 14 - 22 | Delaware Stadium |
| Sat Sep 19 | 12:00 PM ET | Georgia Bulldogs at Arkansas Razorbacks | 45 - 17 | Donald W. Reynolds Razorback Stadium |
| Sat Sep 19 | 12:00 PM ET | Tulane Green Wave at Kansas State Wildcats | 20 - 31 | Bill Snyder Family Football Stadium |
| Sat Sep 19 | 12:00 PM ET | Bowling Green Falcons at Iowa State Cyclones | 7 - 55 | Jack Trice Stadium |
| Sat Sep 19 | 12:00 PM ET | Arizona State Sun Devils vs Kansas Jayhawks | 24 - 17 | Wembley Stadium neutral |
| Sat Sep 19 | 12:00 PM ET | Mercer Bears at Georgia Tech Yellow Jackets | 11 - 44 | Bobby Dodd Stadium |
| Sat Sep 19 | 12:00 PM ET | North Carolina Tar Heels at Clemson Tigers | 20 - 28 | Memorial Stadium (Clemson) |
| Sat Sep 19 | 12:00 PM ET | Akron Zips at Minnesota Golden Gophers | 7 - 41 | Huntington Bank Stadium |
| Sat Sep 19 | 12:00 PM ET | Kent State Golden Flashes at Ohio State Buckeyes | 3 - 59 | Ohio Stadium |
| Sat Sep 19 | 12:00 PM ET | Buffalo Bulls at Penn State Nittany Lions | 13 - 55 | Beaver Stadium |
| Sat Sep 19 | 12:00 PM ET | North Texas Mean Green vs Texas State Bobcats | 35 - 49 | Aviva Stadium neutral |
| Sat Sep 19 | 12:00 PM ET | Brown Bears vs New Haven Chargers | 17 - 10 | Delaware Stadium neutral |
| Sat Sep 19 | 12:00 PM ET | Lafayette Leopards at Columbia Lions | 34 - 40 | Robert K. Kraft Field at Lawrence A. Wien Stadium |
| Sat Sep 19 | 12:00 PM ET | Dartmouth Big Green at Lehigh Mountain Hawks | 20 - 24 | Goodman Stadium |
| Sat Sep 19 | 12:00 PM ET | Villanova Wildcats vs Long Island University Sharks | 20 - 16 | Sharp Gymnasium neutral |
| Sat Sep 19 | 12:00 PM ET | West Georgia Wolves at East Tennessee State Buccaneers | 27 - 35 | William B. Greene Jr. Stadium |
| Sat Sep 19 | 12:30 PM ET | Eastern Michigan Eagles at Wisconsin Badgers | 10 - 54 | Camp Randall Stadium |
| Sat Sep 19 | 12:45 PM ET | NC State Wolfpack at Vanderbilt Commodores | 31 - 35 | FirstBank Stadium |
| Sat Sep 19 | 1:00 PM ET | Wyoming Cowboys at Central Michigan Chippewas | 10 - 24 | Kelly/Shorts Stadium |
| Sat Sep 19 | 1:00 PM ET | Cornell Big Red at Colgate Raiders | 7 - 20 | Crown Field at Andy Kerr Stadium |
| Sat Sep 19 | 1:00 PM ET | Valparaiso Beacons at Indiana State Sycamores | 16 - 39 | Memorial Stadium (Terre Haute, IN) |
| Sat Sep 19 | 1:00 PM ET | Princeton Tigers at Bryant Bulldogs | 14 - 21 | Beirne Stadium |
| Sat Sep 19 | 1:00 PM ET | Harvard Crimson at New Hampshire Wildcats | 31 - 7 | Wildcat Stadium |
| Sat Sep 19 | 1:00 PM ET | VMI Keydets vs Davidson Wildcats | 24 - 27 | McColl-Richardson Field at Jerry Richardson Stadium neutral |
| Sat Sep 19 | 1:00 PM ET | Chicago State Cougars vs Butler Bulldogs | 20 - 47 | Bud and Jackie Sellick Bowl neutral |
| Sat Sep 19 | 1:00 PM ET | Glenville State Pioneers vs Mercyhurst Lakers | 20 - 49 | Saxon Stadium neutral |
| Sat Sep 19 | 2:00 PM ET | Maine Black Bears vs Boston College Eagles | 16 - 22 | Alumni Stadium neutral |
| Sat Sep 19 | 2:00 PM ET | Southern Illinois Salukis vs Illinois Fighting Illini | 10 - 48 | Christy Mathewson-Memorial Stadium neutral |
| Sat Sep 19 | 2:00 PM ET | Yale Bulldogs at Holy Cross Crusaders | 38 - 28 | Fitton Field |
| Sat Sep 19 | 2:00 PM ET | Southern Utah Thunderbirds at St. Thomas - Minnesota Tommies | 26 - 28 | O'Shaughnessy Stadium |
| Sat Sep 19 | 2:30 PM ET | Rhode Island Rams at Stony Brook Seawolves | 24 - 56 | Kenneth P. LaValle Stadium |
| Sat Sep 19 | 2:30 PM ET | Presbyterian Blue Hose at Western Carolina Catamounts | 14 - 58 | Bob Waters Field at E. J. Whitmire Stadium |
| Sat Sep 19 | 3:00 PM ET | Temple Owls at Toledo Rockets | 48 - 49 | Glass Bowl |
| Sat Sep 19 | 3:00 PM ET | Eastern Illinois Panthers at Illinois State Redbirds | 13 - 49 | Hancock Stadium |
| Sat Sep 19 | 3:00 PM ET | Central Connecticut Blue Devils vs Montana State Bobcats | 30 - 35 | Bobcat Stadium neutral |
| Sat Sep 19 | 3:00 PM ET | Pennsylvania Quakers at Bucknell Bison | 20 - 7 | Christy Mathewson-Memorial Stadium |
| Sat Sep 19 | 3:30 PM ET | Florida State Seminoles at Alabama Crimson Tide | 36 - 50 | Bryant-Denny Stadium |
| Sat Sep 19 | 3:30 PM ET | Kentucky Wildcats at Texas A&M Aggies | 31 - 21 | Kyle Field |
| Sat Sep 19 | 3:30 PM ET | Miami (OH) Redhawks vs Cincinnati Bearcats | 31 - 35 | Braly Municipal Stadium neutral |
| Sat Sep 19 | 3:30 PM ET | Utah State Aggies at Utah Utes | 0 - 33 | Rice-Eccles Stadium |
| Sat Sep 19 | 3:30 PM ET | SMU Mustangs at Louisville Cardinals | 31 - 41 | L&N Federal Credit Union Stadium |
| Sat Sep 19 | 3:30 PM ET | Wagner Seahawks at California Golden Bears | 7 - 49 | California Memorial Stadium |
| Sat Sep 19 | 3:30 PM ET | UTEP Miners at Michigan Wolverines | 17 - 52 | Michigan Stadium |
| Sat Sep 19 | 3:30 PM ET | USC Trojans at Rutgers Scarlet Knights | 42 - 35 | SHI Stadium |
| Sat Sep 19 | 3:30 PM ET | Duquesne Dukes at Washington State Cougars | 7 - 48 | Martin Stadium |
| Sat Sep 19 | 3:30 PM ET | Stonehill Skyhawks at UMass Minutemen | 14 - 36 | Warren McGuirk Alumni Stadium |
| Sat Sep 19 | 3:30 PM ET | Georgetown Hoyas at Richmond Spiders | 21 - 24 | E. Claiborne Robins Stadium |
| Sat Sep 19 | 3:30 PM ET | Monmouth Hawks at UAlbany Great Danes | 28 - 20 | Bob Ford Field at Tom & Mary Casey Stadium |
| Sat Sep 19 | 4:00 PM ET | Stanford Cardinal at Duke Blue Devils | 7 - 35 | Wallace Wade Stadium |
| Sat Sep 19 | 4:00 PM ET | Western Kentucky Hilltoppers at Indiana Hoosiers | 0 - 38 | Memorial Stadium (Bloomington, IN) |
| Sat Sep 19 | 4:00 PM ET | Northern Iowa Panthers at Iowa Hawkeyes | 0 - 55 | Kinnick Stadium |
| Sat Sep 19 | 4:00 PM ET | Ball State Cardinals at Liberty Flames | 15 - 51 | Williams Stadium |
| Sat Sep 19 | 4:00 PM ET | Louisiana Tech Bulldogs at Baylor Bears | 19 - 36 | McLane Stadium |
| Sat Sep 19 | 4:00 PM ET | Hampton Pirates at Norfolk State Spartans | 21 - 42 | William Dick Price Stadium |
| Sat Sep 19 | 4:00 PM ET | Abilene Christian Wildcats at Idaho Vandals | 41 - 39 | Kibbie Dome |
| Sat Sep 19 | 4:00 PM ET | Virginia Lynchburg Dragons vs Bethune-Cookman Wildcats | 3 - 62 | Daytona Stadium neutral |
| Sat Sep 19 | 4:15 PM ET | Mississippi State Bulldogs at South Carolina Gamecocks | 41 - 34 | Williams-Brice Stadium |
| Sat Sep 19 | 4:30 PM ET | SE Louisiana Lions at UL Monroe Warhawks | 38 - 35 | JPS Field at Malone Stadium |
| Sat Sep 19 | 6:00 PM ET | East Carolina Pirates at Old Dominion Monarchs | 20 - 17 | S.B. Ballard Stadium |
| Sat Sep 19 | 6:00 PM ET | Florida International Panthers vs Florida Atlantic Owls | 10 - 16 | L&N Federal Credit Union Stadium neutral |
| Sat Sep 19 | 6:00 PM ET | Charlotte 49ers at Appalachian State Mountaineers | 21 - 26 | Kidd Brewer Stadium |
| Sat Sep 19 | 6:00 PM ET | Sacred Heart Pioneers at Elon Phoenix | 21 - 24 | Rhodes Stadium |
| Sat Sep 19 | 6:00 PM ET | North Carolina Central Eagles at Gardner-Webb Runnin' Bulldogs | 20 - 44 | Ernest W. Spangler Stadium |
| Sat Sep 19 | 6:00 PM ET | Dayton Flyers at Eastern Kentucky Colonels | 17 - 14 | Roy Kidd Stadium |
| Sat Sep 19 | 6:00 PM ET | Wofford Terriers at Chattanooga Mocs | 7 - 41 | Finley Stadium |
| Sat Sep 19 | 6:00 PM ET | Central State (OH) Marauders vs Arkansas-Pine Bluff Golden Lions | 35 - 41 | Simmons Bank Field neutral |
| Sat Sep 19 | 6:00 PM ET | North Carolina A&T Aggies at Campbell Fighting Camels | 14 - 42 | Barker-Lane Stadium |
| Sat Sep 19 | 6:00 PM ET | Morgan State Bears at Towson Tigers | 41 - 26 | Johnny Unitas Stadium |
| Sat Sep 19 | 6:00 PM ET | Fordham Rams at William & Mary Tribe | 52 - 27 | Zable Stadium |
| Sat Sep 19 | 6:00 PM ET | Point University Skyhawks vs Charleston Southern Buccaneers | 0 - 65 | Buccaneer Field neutral |
| Sat Sep 19 | 6:30 PM ET | Marshall Thundering Herd at Missouri State Bears | 30 - 24 | Robert W. Plaster Stadium |
| Sat Sep 19 | 7:00 PM ET | Troy Trojans vs Missouri Tigers | 17 - 27 | Busch Memorial Stadium neutral |
| Sat Sep 19 | 7:00 PM ET | Florida Gators at Auburn Tigers | 44 - 39 | Jordan-Hare Stadium |
| Sat Sep 19 | 7:00 PM ET | Georgia State Panthers vs UCF Knights | 30 - 44 | Acrisure Stadium neutral |
| Sat Sep 19 | 7:00 PM ET | Murray State Racers at Oklahoma State Cowboys | 0 - 59 | Boone Pickens |
| Sat Sep 19 | 7:00 PM ET | UConn Huskies at Southern Miss Golden Eagles | 48 - 20 | M. M. Roberts Stadium |
| Sat Sep 19 | 7:00 PM ET | UT Martin Skyhawks at Memphis Tigers | 21 - 45 | Simmons Bank Liberty Stadium |
| Sat Sep 19 | 7:00 PM ET | Western Michigan Broncos at Rice Owls | 28 - 21 | Rice Stadium |
| Sat Sep 19 | 7:00 PM ET | Delaware State Hornets at South Florida Bulls | 17 - 59 | Raymond James Stadium |
| Sat Sep 19 | 7:00 PM ET | Nevada Wolf Pack at Middle Tennessee Blue Raiders | 20 - 27 | Floyd Stadium |
| Sat Sep 19 | 7:00 PM ET | Ohio Bobcats at South Alabama Jaguars | 36 - 41 | Hancock Whitney Stadium |
| Sat Sep 19 | 7:00 PM ET | Georgia Southern Eagles vs Jacksonville State Gamecocks | 27 - 31 | America First Event Center neutral |
| Sat Sep 19 | 7:00 PM ET | Nicholls Colonels at Sam Houston Bearkats | 0 - 59 | Bowers Stadium |
| Sat Sep 19 | 7:00 PM ET | South Carolina State Bulldogs at Furman Paladins | 20 - 17 | Paladin Stadium |
| Sat Sep 19 | 7:00 PM ET | Central Arkansas Bears at Southeast Missouri Redhawks | 9 - 27 | Houck Stadium |
| Sat Sep 19 | 7:00 PM ET | Tennessee State Tigers at Florida A&M Rattlers | 29 - 26 | Bragg Memorial Stadium |
| Sat Sep 19 | 7:00 PM ET | Morehead State Eagles at Western Illinois Leathernecks | 2 - 59 | Hanson Field |
| Sat Sep 19 | 7:00 PM ET | Merrimack Warriors at Tarleton State Texans | 20 - 45 | Memorial Stadium (Stephenville, TX) |
| Sat Sep 19 | 7:00 PM ET | Bowie State Bulldogs vs Alabama A&M Bulldogs | 3 - 45 | Louis Crews Stadium neutral |
| Sat Sep 19 | 7:00 PM ET | Delta State Statesmen vs Mississippi Valley State Delta Devils | 21 - 6 | Rice-Totten Stadium neutral |
| Sat Sep 19 | 7:00 PM ET | Louisiana Christian Wildcats vs Southern Jaguars | 31 - 50 | A. W. Mumford Stadium neutral |
| Sat Sep 19 | 7:00 PM ET | Houston Christian Huskies at Incarnate Word Cardinals | 23 - 30 | Gayle and Tom Benson Stadium |
| Sat Sep 19 | 7:00 PM ET | Youngstown State Penguins at South Dakota State Jackrabbits | 20 - 27 | Dana J. Dykhouse Stadium |
| Sat Sep 19 | 7:00 PM ET | Austin Peay Governors vs West Florida Argonauts | 38 - 16 | Sanford Pentagon neutral |
| Sat Sep 19 | 7:00 PM ET | Alcorn State Braves at North Alabama Lions | 20 - 38 | Braly Municipal Stadium |
| Sat Sep 19 | 7:00 PM ET | Tuskegee Golden Tigers vs Jackson State Tigers | 7 - 41 | Mississippi Veterans Memorial Stadium neutral |
| Sat Sep 19 | 7:15 PM ET | North Dakota Fighting Hawks at Nebraska Cornhuskers | 7 - 34 | Memorial Stadium (Lincoln, NE) |
| Sat Sep 19 | 7:15 PM ET | Eastern Washington Eagles at Washington Huskies | 16 - 48 | Husky Stadium |
| Sat Sep 19 | 7:30 PM ET | LSU Tigers at Ole Miss Rebels | 24 - 32 | Vaught-Hemingway Stadium |
| Sat Sep 19 | 7:30 PM ET | New Mexico Lobos at Oklahoma Sooners | 6 - 14 | Gaylord Fanily Oklahoma Memorial Stadium |
| Sat Sep 19 | 7:30 PM ET | BYU Cougars at Colorado State Rams | 41 - 23 | Canvas Stadium |
| Sat Sep 19 | 7:30 PM ET | Colorado Buffaloes vs Northwestern Wildcats | 7 - 41 | Martin Stadium neutral |
| Sat Sep 19 | 7:30 PM ET | West Virginia Mountaineers vs Virginia Cavaliers | 38 - 27 | Bank of America Stadium neutral |
| Sat Sep 19 | 7:30 PM ET | Virginia Tech Hokies at Maryland Terrapins | 35 - 26 | SECU Stadium |
| Sat Sep 19 | 7:30 PM ET | Michigan State Spartans vs Notre Dame Fighting Irish | 10 - 27 | Notre Dame Stadium neutral |
| Sat Sep 19 | 7:45 PM ET | Kennesaw State Owls at Tennessee Volunteers | 9 - 42 | Neyland Stadium |
| Sat Sep 19 | 8:00 PM ET | UTSA Roadrunners at Texas Longhorns | 6 - 30 | Darrell K Royal-Texas Memorial Stadium |
| Sat Sep 19 | 8:00 PM ET | Arkansas State Red Wolves at TCU Horned Frogs | 7 - 31 | Amon G. Carter Stadium |
| Sat Sep 19 | 8:00 PM ET | East Texas A&M Lions at Tulsa Golden Hurricane | 0 - 42 | Skelly Field at H. A. Chapman Stadium |
| Sat Sep 19 | 8:00 PM ET | UAB Blazers vs Louisiana Ragin' Cajuns | 14 - 21 | Louis Crews Stadium neutral |
| Sat Sep 19 | 8:00 PM ET | San Diego Toreros at Cal Poly Mustangs | 38 - 35 | Alex G. Spanos Stadium |
| Sat Sep 19 | 8:00 PM ET | Northern Arizona Lumberjacks at Utah Tech Trailblazers | 35 - 23 | Greater Zion Stadium |
| Sat Sep 19 | 8:00 PM ET | Northeastern State Riverhawks vs Northern Colorado Bears | 17 - 23 | Nottingham Field neutral |
| Sat Sep 19 | 8:00 PM ET | Northwestern State Demons vs Weber State Wildcats | 20 - 49 | Roy Stewart Stadium neutral |
| Sat Sep 19 | 8:00 PM ET | McNeese Cowboys vs UT Rio Grande Valley Vaqueros | 10 - 27 | Memorial Stadium (Terre Haute, IN) neutral |
| Sat Sep 19 | 8:00 PM ET | Stephen F. Austin Lumberjacks at Prairie View A&M Panthers | 31 - 10 | Panther Stadium at Blackshear Field |
| Sat Sep 19 | 10:00 PM ET | South Dakota Coyotes at Boise State Broncos | 24 - 38 | Albertsons Stadium |
| Sat Sep 19 | 10:00 PM ET | James Madison Dukes at San Diego State Aztecs | 26 - 13 | Snapdragon Stadium |
| Sat Sep 19 | 10:00 PM ET | Stetson Hatters at UC Davis Aggies | 7 - 45 | UC Davis health Stadium |
| Sat Sep 19 | 10:30 PM ET | Northern Illinois Huskies vs Arizona Wildcats | 17 - 42 | Delaware Stadium neutral |
| Sat Sep 19 | 10:30 PM ET | North Dakota State Bison at Sacramento State Hornets | 31 - 10 | Hornet Stadium |
| Sat Sep 19 | 11:00 PM ET | Purdue Boilermakers at UCLA Bruins | 38 - 52 | Rose Bowl |
| Sat Sep 19 | 11:00 PM ET | Montana Grizzlies at Oregon State Beavers | 17 - 52 | Reser Stadium |
| Sat Sep 19 | 11:00 PM ET | Fresno State Bulldogs at San Jose State Spartans | 26 - 10 | CEFCU Stadium |