| Tue Oct 6 | 8:00 PM ET | Southern Miss Golden Eagles at Troy Trojans | 34 - 55 | Veterans Memorial Stadium |
| Wed Oct 7 | 7:00 PM ET | Jacksonville State Gamecocks at Kennesaw State Owls | 27 - 26 | Fifth Third Bank Stadium |
| Wed Oct 7 | 7:30 PM ET | New Mexico State Aggies vs Florida International Panthers | 3 - 22 | William H. Pitt Center neutral |
| Thu Oct 8 | 7:00 PM ET | Sam Houston Bearkats vs Liberty Flames | 3 - 35 | Williams-Brice Stadium neutral |
| Thu Oct 8 | 7:00 PM ET | Missouri State Bears at Western Kentucky Hilltoppers | 13 - 34 | Houchens Industries - L.T. Smith Stadium |
| Thu Oct 8 | 7:30 PM ET | South Florida Bulls at UTSA Roadrunners | 24 - 31 | Alamodome |
| Thu Oct 8 | 7:30 PM ET | South Alabama Jaguars at Arkansas State Red Wolves | — | Centennial Bank Stadium |
| Fri Oct 9 | 12:00 PM ET | Florida A&M Rattlers at Alabama State Hornets | 28 - 27 | New ASU Stadium |
| Fri Oct 9 | 7:00 PM ET | Florida State Seminoles at Louisville Cardinals | 20 - 44 | L&N Federal Credit Union Stadium |
| Fri Oct 9 | 7:00 PM ET | Columbia Lions at Marist Red Foxes | 41 - 28 | Tenney Stadium at Leonidoff Field |
| Fri Oct 9 | 9:00 PM ET | Iowa Hawkeyes at Washington Huskies | 41 - 24 | Husky Stadium |
| Fri Oct 9 | 9:00 PM ET | Washington State Cougars at Utah State Aggies | 16 - 17 | Maverik Stadium |
| Fri Oct 9 | 9:00 PM ET | Wyoming Cowboys at San Jose State Spartans | 16 - 13 | CEFCU Stadium |
| Fri Oct 9 | 10:15 PM ET | Iowa State Cyclones at BYU Cougars | 10 - 24 | LaVell Edwards Stadium |
| Sat Oct 10 | 12:00 PM ET | Texas A&M Aggies vs Missouri Tigers | — | Mississippi Veterans Memorial Stadium neutral |
| Sat Oct 10 | 12:00 PM ET | Arizona Wildcats at West Virginia Mountaineers | 52 - 31 | Milan Puskar Stadium |
| Sat Oct 10 | 12:00 PM ET | UCF Knights at Oklahoma State Cowboys | 28 - 42 | Boone Pickens |
| Sat Oct 10 | 12:00 PM ET | North Carolina Tar Heels at Pittsburgh Panthers | 21 - 17 | Acrisure Stadium |
| Sat Oct 10 | 12:00 PM ET | Wake Forest Demon Deacons at NC State Wolfpack | — | Carter-Finley Stadium |
| Sat Oct 10 | 12:00 PM ET | Indiana Hoosiers at Nebraska Cornhuskers | — | Memorial Stadium (Lincoln, NE) |
| Sat Oct 10 | 12:00 PM ET | Sacramento State Hornets at Bowling Green Falcons | 10 - 38 | Doyt Perry Stadium |
| Sat Oct 10 | 12:00 PM ET | Tulane Green Wave at Army Black Knights | 17 - 20 | Michie Stadium |
| Sat Oct 10 | 12:00 PM ET | Bryant Bulldogs at Brown Bears | — | Richard Gouse Field at Brown Stadium |
| Sat Oct 10 | 12:00 PM ET | Robert Morris Colonials at Morgan State Bears | 27 - 28 | Hughes Stadium |
| Sat Oct 10 | 12:00 PM ET | Princeton Tigers at Wagner Seahawks | 28 - 13 | Wagner College Stadium |
| Sat Oct 10 | 12:00 PM ET | Davidson Wildcats at Presbyterian Blue Hose | 21 - 38 | Bailey memorial Stadium |
| Sat Oct 10 | 12:00 PM ET | New Hampshire Wildcats at North Carolina A&T Aggies | — | Truist Stadium |
| Sat Oct 10 | 12:00 PM ET | Stonehill Skyhawks at Sacred Heart Pioneers | — | Campus Field |
| Sat Oct 10 | 12:00 PM ET | Dartmouth Big Green at Yale Bulldogs | 7 - 28 | Yale Bowl |
| Sat Oct 10 | 12:00 PM ET | Morehead State Eagles at Dayton Flyers | 28 - 56 | Welcome Stadium |
| Sat Oct 10 | 12:00 PM ET | East Tennessee State Buccaneers at The Citadel Bulldogs | — | Johnson Hagood Stadium |
| Sat Oct 10 | 12:00 PM ET | South Carolina State Bulldogs at Charleston Southern Buccaneers | — | Buccaneer Field |
| Sat Oct 10 | 12:30 PM ET | Ball State Cardinals at Northwestern Wildcats | 14 - 45 | Ryan Field |
| Sat Oct 10 | 12:30 PM ET | Bucknell Bison at Georgetown Hoyas | 14 - 21 | Cooper Field |
| Sat Oct 10 | 12:45 PM ET | South Carolina Gamecocks at Florida Gators | — | Ben Hill Griffin Stadium |
| Sat Oct 10 | 1:00 PM ET | Rice Owls at East Carolina Pirates | — | Dowdy-Ficklen Stadium |
| Sat Oct 10 | 1:00 PM ET | Old Dominion Monarchs at Appalachian State Mountaineers | 10 - 3 | Kidd Brewer Stadium |
| Sat Oct 10 | 1:00 PM ET | Harvard Crimson at Cornell Big Red | 41 - 29 | Schoellkopf Field |
| Sat Oct 10 | 1:00 PM ET | Youngstown State Penguins at Indiana State Sycamores | — | Memorial Stadium (Terre Haute, IN) |
| Sat Oct 10 | 1:00 PM ET | American International Yellow Jackets vs Central Connecticut Blue Devils | — | Arute Field neutral |
| Sat Oct 10 | 1:00 PM ET | Franklin Pierce Ravens vs Delaware State Hornets | 0 - 34 | Alumni Stadium neutral |
| Sat Oct 10 | 1:00 PM ET | Howard Bison vs Pennsylvania Quakers | 20 - 24 | American Family Field neutral |
| Sat Oct 10 | 1:00 PM ET | William & Mary Tribe at North Carolina Central Eagles | — | O'Kelly-Riddick Stadum |
| Sat Oct 10 | 1:00 PM ET | San Diego Toreros at Butler Bulldogs | 10 - 41 | Bud and Jackie Sellick Bowl |
| Sat Oct 10 | 1:00 PM ET | Bethune-Cookman Wildcats at Alabama A&M Bulldogs | 17 - 55 | Louis Crews Stadium |
| Sat Oct 10 | 1:00 PM ET | Samford Bulldogs at Chattanooga Mocs | 3 - 19 | Finley Stadium |
| Sat Oct 10 | 1:00 PM ET | Long Island University Sharks at Duquesne Dukes | — | Arthur J. Rooney Athletic Field |
| Sat Oct 10 | 2:00 PM ET | Miami (OH) Redhawks at UMass Minutemen | — | Warren McGuirk Alumni Stadium |
| Sat Oct 10 | 2:00 PM ET | Southern Illinois Salukis at South Dakota Coyotes | 10 - 31 | DakotaDome |
| Sat Oct 10 | 2:00 PM ET | Virginia Lynchburg Dragons vs Norfolk State Spartans | 0 - 62 | William Dick Price Stadium neutral |
| Sat Oct 10 | 2:00 PM ET | Drake Bulldogs at Valparaiso Beacons | — | Brown Field |
| Sat Oct 10 | 2:00 PM ET | Stetson Hatters at St. Thomas - Minnesota Tommies | 21 - 64 | O'Shaughnessy Stadium |
| Sat Oct 10 | 2:00 PM ET | Wofford Terriers at Elon Phoenix | 16 - 0 | Rhodes Stadium |
| Sat Oct 10 | 2:00 PM ET | Southeast Missouri Redhawks at Lindenwood Lions | 38 - 27 | Harlen C. Hunter Stadium |
| Sat Oct 10 | 3:00 PM ET | Idaho Vandals vs Weber State Wildcats | — | Roy Stewart Stadium neutral |
| Sat Oct 10 | 3:00 PM ET | Western Carolina Catamounts vs Mercer Bears | — | Bishop Schmitt Field neutral |
| Sat Oct 10 | 3:00 PM ET | Mississippi Valley State Delta Devils at Texas Southern Tigers | 38 - 34 | Shell Energy Stadium |
| Sat Oct 10 | 3:00 PM ET | Arkansas Baptist Buffaloes vs Alcorn State Braves | 7 - 63 | Casem-Spinks Stadium neutral |
| Sat Oct 10 | 3:30 PM ET | Ole Miss Rebels at Vanderbilt Commodores | — | FirstBank Stadium |
| Sat Oct 10 | 3:30 PM ET | Houston Cougars at Kansas State Wildcats | — | Bill Snyder Family Football Stadium |
| Sat Oct 10 | 3:30 PM ET | Duke Blue Devils at Georgia Tech Yellow Jackets | 25 - 28 | Bobby Dodd Stadium |
| Sat Oct 10 | 3:30 PM ET | Virginia Tech Hokies at California Golden Bears | 20 - 25 | California Memorial Stadium |
| Sat Oct 10 | 3:30 PM ET | Illinois Fighting Illini at Michigan State Spartans | — | Spartan Stadium |
| Sat Oct 10 | 3:30 PM ET | UCLA Bruins at Oregon Ducks | — | Autzen Stadium |
| Sat Oct 10 | 3:30 PM ET | Charlotte 49ers vs North Texas Mean Green | 10 - 50 | David Booth Kansas Memorial Stadium neutral |
| Sat Oct 10 | 3:30 PM ET | Eastern Michigan Eagles at Akron Zips | 25 - 23 | InfoCision Stadium - Summa Field |
| Sat Oct 10 | 3:30 PM ET | Buffalo Bulls at Toledo Rockets | — | Glass Bowl |
| Sat Oct 10 | 3:30 PM ET | Central Michigan Chippewas at Ohio Bobcats | — | Peden Stadium |
| Sat Oct 10 | 3:30 PM ET | Kent State Golden Flashes at Western Michigan Broncos | 7 - 38 | Waldo Stadium |
| Sat Oct 10 | 3:30 PM ET | Texas Longhorns vs Oklahoma Sooners | 24 - 27 | Cotton Bowl neutral |
| Sat Oct 10 | 3:30 PM ET | Stanford Cardinal vs Notre Dame Fighting Irish | — | Notre Dame Stadium neutral |
| Sat Oct 10 | 3:30 PM ET | Tulsa Golden Hurricane at Navy Midshipmen | 26 - 34 | Navy-Marine Corps Memorial Stadium |
| Sat Oct 10 | 3:30 PM ET | Richmond Spiders at Fordham Rams | 14 - 20 | Coffey Field |
| Sat Oct 10 | 3:30 PM ET | Eastern Illinois Panthers at Gardner-Webb Runnin' Bulldogs | 21 - 7 | Ernest W. Spangler Stadium |
| Sat Oct 10 | 3:30 PM ET | UT Martin Skyhawks at Tennessee State Tigers | — | Nissan Stadium |
| Sat Oct 10 | 3:30 PM ET | Furman Paladins at Tennessee Tech Golden Eagles | — | Tucker Stadium |
| Sat Oct 10 | 3:45 PM ET | UConn Huskies at Temple Owls | 34 - 20 | Lincoln Financial Field |
| Sat Oct 10 | 4:00 PM ET | Utah Tech Trailblazers at Portland State Vikings | 14 - 30 | Hillsboro Stadium |
| Sat Oct 10 | 4:00 PM ET | Southern Jaguars at Prairie View A&M Panthers | — | Panther Stadium at Blackshear Field |
| Sat Oct 10 | 4:00 PM ET | Incarnate Word Cardinals at Lamar Cardinals | — | Provost Umphrey Stadium |
| Sat Oct 10 | 4:00 PM ET | Stony Brook Seawolves at Towson Tigers | 31 - 24 | Johnny Unitas Stadium |
| Sat Oct 10 | 4:15 PM ET | Tennessee Volunteers at Arkansas Razorbacks | 24 - 17 | Donald W. Reynolds Razorback Stadium |
| Sat Oct 10 | 4:15 PM ET | Maryland Terrapins at Ohio State Buckeyes | — | Ohio Stadium |
| Sat Oct 10 | 5:00 PM ET | North Dakota Fighting Hawks at Northern Iowa Panthers | 17 - 24 | UNI-Dome |
| Sat Oct 10 | 5:00 PM ET | Montana Grizzlies at Northern Arizona Lumberjacks | 44 - 49 | Walkup Dome |
| Sat Oct 10 | 5:00 PM ET | Jackson State Tigers at Grambling Tigers | 38 - 45 | Eddie G. Robinson Memorial Stadium |
| Sat Oct 10 | 5:00 PM ET | Northeastern State Riverhawks vs West Florida Argonauts | — | Cooper Field neutral |
| Sat Oct 10 | 6:00 PM ET | San Diego State Aztecs at Oregon State Beavers | — | Reser Stadium |
| Sat Oct 10 | 6:00 PM ET | Cal Poly Mustangs vs Idaho State Bengals | 25 - 24 | ICCU Arena neutral |
| Sat Oct 10 | 6:00 PM ET | West Georgia Wolves at Eastern Kentucky Colonels | 20 - 30 | Roy Kidd Stadium |
| Sat Oct 10 | 7:00 PM ET | LSU Tigers at Kentucky Wildcats | — | Kroger Field |
| Sat Oct 10 | 7:00 PM ET | UAB Blazers at Memphis Tigers | — | Simmons Bank Liberty Stadium |
| Sat Oct 10 | 7:00 PM ET | Nevada Wolf Pack at UTEP Miners | 30 - 13 | Sun Bowl |
| Sat Oct 10 | 7:00 PM ET | Coastal Carolina Chanticleers at Marshall Thundering Herd | 27 - 21 | Joan C. Edwards Stadium |
| Sat Oct 10 | 7:00 PM ET | North Dakota State Bison at UNLV Runnin' Rebels | — | Allegiant Stadium |
| Sat Oct 10 | 7:00 PM ET | Tarleton State Texans at Austin Peay Governors | 40 - 32 | Fortera Stadium |
| Sat Oct 10 | 7:00 PM ET | Northern Colorado Bears at Eastern Washington Eagles | 22 - 31 | Roos Field |
| Sat Oct 10 | 7:30 PM ET | Georgia Bulldogs at Alabama Crimson Tide | 20 - 17 | Bryant-Denny Stadium |
| Sat Oct 10 | 7:30 PM ET | Syracuse Orange at Virginia Cavaliers | — | Scott Stadium |
| Sat Oct 10 | 7:30 PM ET | USC Trojans at Penn State Nittany Lions | — | Beaver Stadium |
| Sat Oct 10 | 7:30 PM ET | James Madison Dukes vs Georgia Southern Eagles | 27 - 24 | Paulson Stadium neutral |
| Sat Oct 10 | 7:30 PM ET | Louisiana Ragin' Cajuns at Louisiana Tech Bulldogs | 31 - 32 | Joe Aillet Stadium |
| Sat Oct 10 | 7:30 PM ET | Air Force Falcons vs Northern Illinois Huskies | — | Husky Stadium neutral |
| Sat Oct 10 | 8:00 PM ET | Kansas Jayhawks at Utah Utes | 24 - 41 | Rice-Eccles Stadium |
| Sat Oct 10 | 8:00 PM ET | Minnesota Golden Gophers at Purdue Boilermakers | 13 - 41 | Ross-Ade Stadium |
| Sat Oct 10 | 8:00 PM ET | SE Louisiana Lions vs UT Rio Grande Valley Vaqueros | 3 - 13 | Kenneth P. LaValle Stadium neutral |
| Sat Oct 10 | 8:00 PM ET | Central Arkansas Bears at Abilene Christian Wildcats | — | Anthony Field at Wildcat Stadium |
| Sat Oct 10 | 10:30 PM ET | Hawai'i Rainbow Warriors vs Arizona State Sun Devils | — | Bill Snyder Family Football Stadium neutral |
| Sat Oct 10 | 10:30 PM ET | Boise State Broncos at Fresno State Bulldogs | 38 - 31 | Valley Children's Stadium |