| Thu Sep 24 | 7:30 PM ET | Liberty Flames at Coastal Carolina Chanticleers | 34 - 17 | Brooks Stadium |
| Fri Sep 25 | 4:00 PM ET | Army Black Knights at Temple Owls | 21 - 17 | Lincoln Financial Field |
| Fri Sep 25 | 7:00 PM ET | Howard Bison at Rutgers Scarlet Knights | 7 - 58 | SHI Stadium |
| Fri Sep 25 | 7:00 PM ET | Navy Midshipmen at UAB Blazers | 20 - 24 | Protective Stadium |
| Fri Sep 25 | 7:00 PM ET | Harvard Crimson at Brown Bears | 14 - 10 | Richard Gouse Field at Brown Stadium |
| Fri Sep 25 | 8:00 PM ET | Northwestern Wildcats at Indiana Hoosiers | 23 - 29 | Memorial Stadium (Bloomington, IN) |
| Fri Sep 25 | 10:30 PM ET | Clemson Tigers at California Golden Bears | 24 - 10 | California Memorial Stadium |
| Sat Sep 26 | 12:00 PM ET | Sam Houston Bearkats vs Texas Tech Red Raiders | 14 - 49 | AT&T Stadium neutral |
| Sat Sep 26 | 12:00 PM ET | Colorado Buffaloes at Baylor Bears | 13 - 23 | McLane Stadium |
| Sat Sep 26 | 12:00 PM ET | Virginia Tech Hokies at Boston College Eagles | 21 - 14 | Alumni Stadium |
| Sat Sep 26 | 12:00 PM ET | Wake Forest Demon Deacons at Louisville Cardinals | 30 - 27 | L&N Federal Credit Union Stadium |
| Sat Sep 26 | 12:00 PM ET | Illinois Fighting Illini at Ohio State Buckeyes | 19 - 42 | Ohio Stadium |
| Sat Sep 26 | 12:00 PM ET | San Diego State Aztecs at Toledo Rockets | 16 - 41 | Glass Bowl |
| Sat Sep 26 | 12:00 PM ET | Colorado State Rams at UTSA Roadrunners | 45 - 59 | Alamodome |
| Sat Sep 26 | 12:00 PM ET | UNLV Runnin' Rebels at Akron Zips | 38 - 10 | InfoCision Stadium - Summa Field |
| Sat Sep 26 | 12:00 PM ET | Ball State Cardinals at Kent State Golden Flashes | 13 - 26 | Dix Stadium |
| Sat Sep 26 | 12:00 PM ET | Texas Longhorns at Tennessee Volunteers | 20 - 17 | Neyland Stadium |
| Sat Sep 26 | 12:00 PM ET | Bucknell Bison at Pittsburgh Panthers | 0 - 59 | Acrisure Stadium |
| Sat Sep 26 | 12:00 PM ET | Presbyterian Blue Hose at Marist Red Foxes | 7 - 42 | Tenney Stadium at Leonidoff Field |
| Sat Sep 26 | 12:00 PM ET | New Hampshire Wildcats at Sacred Heart Pioneers | 13 - 20 | Campus Field |
| Sat Sep 26 | 12:00 PM ET | Rio Grande Red Storm vs Duquesne Dukes | 0 - 53 | Arthur J. Rooney Athletic Field neutral |
| Sat Sep 26 | 12:30 PM ET | Columbia Lions at Georgetown Hoyas | 20 - 17 | Cooper Field |
| Sat Sep 26 | 12:30 PM ET | Holy Cross Crusaders at Lafayette Leopards | 38 - 30 | Fisher Stadium |
| Sat Sep 26 | 12:45 PM ET | South Alabama Jaguars at Kentucky Wildcats | 21 - 45 | Kroger Field |
| Sat Sep 26 | 1:00 PM ET | Lindenwood Lions at Eastern Michigan Eagles | 3 - 29 | Rynearson Stadium |
| Sat Sep 26 | 1:00 PM ET | Monmouth Hawks vs Dartmouth Big Green | 31 - 28 | Alumni Memorial Field neutral |
| Sat Sep 26 | 1:00 PM ET | Stony Brook Seawolves at Fordham Rams | 31 - 16 | Coffey Field |
| Sat Sep 26 | 1:00 PM ET | Yale Bulldogs at Cornell Big Red | 25 - 38 | Schoellkopf Field |
| Sat Sep 26 | 1:00 PM ET | North Dakota Fighting Hawks at Indiana State Sycamores | 42 - 35 | Memorial Stadium (Terre Haute, IN) |
| Sat Sep 26 | 1:00 PM ET | Lehigh Mountain Hawks vs Pennsylvania Quakers | 20 - 7 | Frank Erwin Center neutral |
| Sat Sep 26 | 1:00 PM ET | New Haven Chargers vs Merrimack Warriors | 10 - 17 | Duane Stadium neutral |
| Sat Sep 26 | 1:00 PM ET | Drake Bulldogs vs Davidson Wildcats | 51 - 32 | Jerry Richardson Indoor Stadium neutral |
| Sat Sep 26 | 1:30 PM ET | UCLA Bruins at Maryland Terrapins | 54 - 3 | SECU Stadium |
| Sat Sep 26 | 1:30 PM ET | Tennessee Tech Golden Eagles at Wofford Terriers | 42 - 38 | Gibbs Stadium |
| Sat Sep 26 | 2:00 PM ET | Notre Dame Fighting Irish at Purdue Boilermakers | 49 - 10 | Ross-Ade Stadium |
| Sat Sep 26 | 2:00 PM ET | Northern Illinois Huskies at Georgia State Panthers | 14 - 35 | Center Parc Stadium |
| Sat Sep 26 | 2:00 PM ET | South Dakota Coyotes at Youngstown State Penguins | 28 - 47 | Stambaugh Stadium |
| Sat Sep 26 | 2:00 PM ET | Furman Paladins at Richmond Spiders | 9 - 13 | E. Claiborne Robins Stadium |
| Sat Sep 26 | 2:00 PM ET | UT Martin Skyhawks at Austin Peay Governors | 12 - 35 | Fortera Stadium |
| Sat Sep 26 | 2:00 PM ET | Butler Bulldogs at Valparaiso Beacons | 33 - 28 | Brown Field |
| Sat Sep 26 | 2:00 PM ET | San Diego Toreros at St. Thomas - Minnesota Tommies | 17 - 50 | O'Shaughnessy Stadium |
| Sat Sep 26 | 2:00 PM ET | Maine Black Bears at Elon Phoenix | 17 - 43 | Rhodes Stadium |
| Sat Sep 26 | 2:00 PM ET | Chattanooga Mocs at The Citadel Bulldogs | 27 - 8 | Johnson Hagood Stadium |
| Sat Sep 26 | 2:30 PM ET | Colgate Raiders at Villanova Wildcats | 28 - 21 | Villanova Stadium |
| Sat Sep 26 | 3:00 PM ET | Central Arkansas Bears at Florida State Seminoles | 7 - 34 | Doak Campbell Stadium |
| Sat Sep 26 | 3:00 PM ET | Hawai'i Rainbow Warriors at Wyoming Cowboys | 10 - 27 | War Memorial Stadium (Laramie, WY) |
| Sat Sep 26 | 3:00 PM ET | UAlbany Great Danes at Princeton Tigers | 0 - 22 | Powers Field at Princeton Stadium |
| Sat Sep 26 | 3:30 PM ET | Ole Miss Rebels at Florida Gators | 28 - 52 | Ben Hill Griffin Stadium |
| Sat Sep 26 | 3:30 PM ET | Oklahoma Sooners at Georgia Bulldogs | 13 - 41 | Sanford Stadium |
| Sat Sep 26 | 3:30 PM ET | TCU Horned Frogs vs UCF Knights | 13 - 21 | Acrisure Stadium neutral |
| Sat Sep 26 | 3:30 PM ET | Utah Utes at Iowa State Cyclones | 31 - 17 | Jack Trice Stadium |
| Sat Sep 26 | 3:30 PM ET | Iowa Hawkeyes at Michigan Wolverines | 20 - 19 | Michigan Stadium |
| Sat Sep 26 | 3:30 PM ET | Boise State Broncos at Western Michigan Broncos | 32 - 7 | Waldo Stadium |
| Sat Sep 26 | 3:30 PM ET | UConn Huskies at Miami (OH) Redhawks | 21 - 24 | Yager Stadium |
| Sat Sep 26 | 3:30 PM ET | William & Mary Tribe at Duke Blue Devils | 7 - 62 | Wallace Wade Stadium |
| Sat Sep 26 | 3:30 PM ET | New Mexico Lobos at New Mexico State Aggies | 42 - 18 | Aggie Memorial Stadium |
| Sat Sep 26 | 3:30 PM ET | Robert Morris Colonials vs Buffalo Bulls | 28 - 31 | Braly Municipal Stadium neutral |
| Sat Sep 26 | 3:30 PM ET | Stonehill Skyhawks at Ohio Bobcats | 7 - 35 | Peden Stadium |
| Sat Sep 26 | 3:30 PM ET | Gardner-Webb Runnin' Bulldogs at Marshall Thundering Herd | 35 - 36 | Joan C. Edwards Stadium |
| Sat Sep 26 | 3:30 PM ET | VMI Keydets at Samford Bulldogs | 7 - 45 | Seibert Stadium |
| Sat Sep 26 | 3:30 PM ET | Western Carolina Catamounts at East Tennessee State Buccaneers | 31 - 58 | William B. Greene Jr. Stadium |
| Sat Sep 26 | 4:00 PM ET | Houston Cougars vs Georgia Southern Eagles | 42 - 28 | Paulson Stadium neutral |
| Sat Sep 26 | 4:00 PM ET | North Carolina Central Eagles at East Carolina Pirates | 9 - 42 | Dowdy-Ficklen Stadium |
| Sat Sep 26 | 4:00 PM ET | Western Illinois Leathernecks at North Alabama Lions | 20 - 23 | Braly Municipal Stadium |
| Sat Sep 26 | 4:00 PM ET | Lamar Cardinals at Nicholls Colonels | 49 - 18 | Manning Field at John L. Guidry Stadium |
| Sat Sep 26 | 4:00 PM ET | Rhode Island Rams at North Carolina A&T Aggies | 18 - 22 | Truist Stadium |
| Sat Sep 26 | 4:00 PM ET | Texas Southern Tigers at Alcorn State Braves | 40 - 43 | Casem-Spinks Stadium |
| Sat Sep 26 | 4:15 PM ET | Vanderbilt Commodores at Auburn Tigers | 15 - 21 | Jordan-Hare Stadium |
| Sat Sep 26 | 5:00 PM ET | Nebraska Cornhuskers at Michigan State Spartans | 31 - 13 | Spartan Stadium |
| Sat Sep 26 | 5:00 PM ET | Wisconsin Badgers at Penn State Nittany Lions | 24 - 20 | Beaver Stadium |
| Sat Sep 26 | 5:00 PM ET | South Florida Bulls at Bowling Green Falcons | 14 - 6 | Doyt Perry Stadium |
| Sat Sep 26 | 5:00 PM ET | Illinois State Redbirds at Northern Iowa Panthers | 21 - 28 | UNI-Dome |
| Sat Sep 26 | 6:00 PM ET | Delaware Blue Hens at Virginia Cavaliers | 3 - 42 | Scott Stadium |
| Sat Sep 26 | 6:00 PM ET | James Madison Dukes at Old Dominion Monarchs | 46 - 20 | S.B. Ballard Stadium |
| Sat Sep 26 | 6:00 PM ET | Incarnate Word Cardinals vs Texas State Bobcats | 10 - 63 | Angel Stadium neutral |
| Sat Sep 26 | 6:00 PM ET | Long Island University Sharks vs Florida International Panthers | 3 - 20 | The Pit neutral |
| Sat Sep 26 | 6:00 PM ET | Towson Tigers vs Delaware State Hornets | 28 - 33 | Alumni Stadium neutral |
| Sat Sep 26 | 6:00 PM ET | Northeastern State Riverhawks vs Stephen F. Austin Lumberjacks | 14 - 63 | Homer Bryce Stadium neutral |
| Sat Sep 26 | 6:00 PM ET | Campbell Fighting Camels at Hampton Pirates | 44 - 20 | Armstrong Stadium |
| Sat Sep 26 | 6:00 PM ET | Fort Valley State Wildcats vs West Georgia Wolves | 7 - 49 | University Stadium neutral |
| Sat Sep 26 | 6:00 PM ET | Mississippi Valley State Delta Devils at Alabama State Hornets | 15 - 41 | New ASU Stadium |
| Sat Sep 26 | 6:30 PM ET | Louisiana Ragin' Cajuns at Charlotte 49ers | 34 - 7 | McColl-Richardson Field at Jerry Richardson Stadium |
| Sat Sep 26 | 6:30 PM ET | Central Michigan Chippewas at Miami Hurricanes | 3 - 52 | Hard Rock Stadium |
| Sat Sep 26 | 7:00 PM ET | South Carolina Gamecocks at Alabama Crimson Tide | 18 - 49 | Bryant-Denny Stadium |
| Sat Sep 26 | 7:00 PM ET | Kansas State Wildcats at Cincinnati Bearcats | 26 - 31 | Nippert Stadium |
| Sat Sep 26 | 7:00 PM ET | Oklahoma State Cowboys at West Virginia Mountaineers | 41 - 24 | Milan Puskar Stadium |
| Sat Sep 26 | 7:00 PM ET | Southern Miss Golden Eagles at Tulane Green Wave | 21 - 24 | Yulman Stadium |
| Sat Sep 26 | 7:00 PM ET | Kennesaw State Owls at Arkansas State Red Wolves | 14 - 17 | Centennial Bank Stadium |
| Sat Sep 26 | 7:00 PM ET | Mercyhurst Lakers at Western Kentucky Hilltoppers | 7 - 52 | Houchens Industries - L.T. Smith Stadium |
| Sat Sep 26 | 7:00 PM ET | Middle Tennessee Blue Raiders vs Jacksonville State Gamecocks | 13 - 23 | Bank of America Stadium neutral |
| Sat Sep 26 | 7:00 PM ET | Southern Illinois Salukis at Murray State Racers | 46 - 6 | Roy Stewart Stadium |
| Sat Sep 26 | 7:00 PM ET | South Carolina State Bulldogs at Bethune-Cookman Wildcats | 31 - 21 | Daytona Stadium |
| Sat Sep 26 | 7:00 PM ET | Cal Poly Mustangs at Eastern Washington Eagles | 31 - 27 | Roos Field |
| Sat Sep 26 | 7:00 PM ET | Alabama A&M Bulldogs at Florida A&M Rattlers | 40 - 21 | Bragg Memorial Stadium |
| Sat Sep 26 | 7:00 PM ET | East Texas A&M Lions vs McNeese Cowboys | 24 - 27 | Navy-Marine Corps Memorial Stadium neutral |
| Sat Sep 26 | 7:00 PM ET | West Florida Argonauts vs Southeast Missouri Redhawks | 20 - 17 | Houck Stadium neutral |
| Sat Sep 26 | 7:00 PM ET | Eastern Illinois Panthers at South Dakota State Jackrabbits | 7 - 42 | Dana J. Dykhouse Stadium |
| Sat Sep 26 | 7:00 PM ET | SE Louisiana Lions at Northwestern State Demons | 52 - 21 | Harry Turpin Stadium |
| Sat Sep 26 | 7:00 PM ET | Southern Jaguars at Jackson State Tigers | 17 - 35 | Mississippi Veterans Memorial Stadium |
| Sat Sep 26 | 7:00 PM ET | Norfolk State Spartans vs Chicago State Cougars | 43 - 20 | Seattle Kingdome neutral |
| Sat Sep 26 | 7:00 PM ET | Prairie View A&M Panthers vs Grambling Tigers | 21 - 14 | Cotton Bowl neutral |
| Sat Sep 26 | 7:30 PM ET | Texas A&M Aggies at LSU Tigers | 6 - 35 | Tiger Stadium (Louisiana) |
| Sat Sep 26 | 7:30 PM ET | Oregon Ducks at USC Trojans | 41 - 27 | Los Angeles Memorial Coliseum |
| Sat Sep 26 | 7:30 PM ET | Appalachian State Mountaineers at NC State Wolfpack | 31 - 41 | Carter-Finley Stadium |
| Sat Sep 26 | 7:30 PM ET | Arizona Wildcats at Washington State Cougars | 34 - 24 | Martin Stadium |
| Sat Sep 26 | 7:30 PM ET | Troy Trojans at Utah State Aggies | 10 - 21 | Maverik Stadium |
| Sat Sep 26 | 7:30 PM ET | Houston Christian Huskies vs North Texas Mean Green | 14 - 63 | Aviva Stadium neutral |
| Sat Sep 26 | 7:45 PM ET | Missouri Tigers at Mississippi State Bulldogs | 24 - 31 | Davis Wade Stadium |
| Sat Sep 26 | 8:00 PM ET | Florida Atlantic Owls at UL Monroe Warhawks | 45 - 17 | JPS Field at Malone Stadium |
| Sat Sep 26 | 8:00 PM ET | Tulsa Golden Hurricane at Arkansas Razorbacks | 6 - 34 | Donald W. Reynolds Razorback Stadium |
| Sat Sep 26 | 8:00 PM ET | Idaho State Bengals at Southern Utah Thunderbirds | 28 - 24 | Eccles Coliseum |
| Sat Sep 26 | 8:00 PM ET | Utah Tech Trailblazers at Northern Colorado Bears | 13 - 37 | Nottingham Field |
| Sat Sep 26 | 8:00 PM ET | Portland State Vikings vs Weber State Wildcats | 44 - 41 | Roy Stewart Stadium neutral |
| Sat Sep 26 | 8:00 PM ET | Mercer Bears at Abilene Christian Wildcats | 34 - 17 | Anthony Field at Wildcat Stadium |
| Sat Sep 26 | 9:00 PM ET | Missouri State Bears at SMU Mustangs | 24 - 34 | Gerald J. Ford Stadium |
| Sat Sep 26 | 9:00 PM ET | UMass Minutemen at Sacramento State Hornets | 35 - 6 | Hornet Stadium |
| Sat Sep 26 | 9:00 PM ET | Oregon State Beavers at UTEP Miners | 33 - 7 | Sun Bowl |
| Sat Sep 26 | 10:00 PM ET | Rice Owls at Fresno State Bulldogs | 24 - 38 | Valley Children's Stadium |
| Sat Sep 26 | 10:00 PM ET | Montana Grizzlies at UC Davis Aggies | 62 - 22 | UC Davis health Stadium |
| Sat Sep 26 | 10:30 PM ET | Air Force Falcons at Nevada Wolf Pack | 36 - 33 | Mackay Stadium |
| Sat Sep 26 | 10:30 PM ET | Georgia Tech Yellow Jackets at Stanford Cardinal | 27 - 34 | Stanford Stadium |
| Sat Sep 26 | 10:30 PM ET | Northern Arizona Lumberjacks vs Montana State Bobcats | 14 - 28 | Bobcat Stadium neutral |
| Sat Sep 26 | 11:00 PM ET | Minnesota Golden Gophers at Washington Huskies | 27 - 24 | Husky Stadium |