| Thu Oct 1 | 8:00 PM ET | Western Kentucky Hilltoppers at New Mexico State Aggies | 13 - 34 | Aggie Memorial Stadium |
| Thu Oct 1 | 9:00 PM ET | North Texas Mean Green at Tulsa Golden Hurricane | 45 - 44 | Skelly Field at H. A. Chapman Stadium |
| Fri Oct 2 | 7:00 PM ET | Pittsburgh Panthers at Virginia Tech Hokies | 35 - 33 | Lane Stadium |
| Fri Oct 2 | 7:00 PM ET | Liberty Flames at Delaware Blue Hens | 30 - 14 | Delaware Stadium |
| Fri Oct 2 | 8:00 PM ET | Penn State Nittany Lions at Northwestern Wildcats | 13 - 34 | Ryan Field |
| Fri Oct 2 | 10:30 PM ET | Montana State Bobcats at Idaho Vandals | 34 - 35 | Kibbie Dome |
| Sat Oct 3 | 11:00 AM ET | Memphis Tigers at Charlotte 49ers | 59 - 8 | McColl-Richardson Field at Jerry Richardson Stadium |
| Sat Oct 3 | 12:00 PM ET | Alabama Crimson Tide at Mississippi State Bulldogs | 56 - 23 | Davis Wade Stadium |
| Sat Oct 3 | 12:00 PM ET | Middle Tennessee Blue Raiders at Kansas Jayhawks | 0 - 55 | David Booth Kansas Memorial Stadium |
| Sat Oct 3 | 12:00 PM ET | UCF Knights vs Houston Cougars | 17 - 27 | TDECU Stadium neutral |
| Sat Oct 3 | 12:00 PM ET | West Virginia Mountaineers at Iowa State Cyclones | 42 - 45 | Jack Trice Stadium |
| Sat Oct 3 | 12:00 PM ET | Boston College Eagles at SMU Mustangs | 16 - 25 | Gerald J. Ford Stadium |
| Sat Oct 3 | 12:00 PM ET | Notre Dame Fighting Irish vs North Carolina Tar Heels | 37 - 26 | Kenan Memorial Stadium neutral |
| Sat Oct 3 | 12:00 PM ET | Stanford Cardinal vs Wake Forest Demon Deacons | 3 - 57 | Allegiant Stadium neutral |
| Sat Oct 3 | 12:00 PM ET | Michigan Wolverines at Minnesota Golden Gophers | 14 - 20 | Huntington Bank Stadium |
| Sat Oct 3 | 12:00 PM ET | Syracuse Orange at UConn Huskies | 42 - 41 | Pratt & Whitney Stadium at Rentschier Field |
| Sat Oct 3 | 12:00 PM ET | Navy Midshipmen vs Air Force Falcons | 9 - 14 | Falcon Stadium neutral |
| Sat Oct 3 | 12:00 PM ET | Princeton Tigers at Columbia Lions | 35 - 7 | Robert K. Kraft Field at Lawrence A. Wien Stadium |
| Sat Oct 3 | 12:00 PM ET | Wagner Seahawks at Central Connecticut Blue Devils | 14 - 45 | Arute Field |
| Sat Oct 3 | 12:00 PM ET | Mercyhurst Lakers vs Long Island University Sharks | 24 - 27 | O'Shaughnessy Stadium neutral |
| Sat Oct 3 | 12:00 PM ET | Fordham Rams at Lehigh Mountain Hawks | 0 - 34 | Goodman Stadium |
| Sat Oct 3 | 12:00 PM ET | St. Thomas - Minnesota Tommies at Presbyterian Blue Hose | 21 - 55 | Bailey memorial Stadium |
| Sat Oct 3 | 12:00 PM ET | Merrimack Warriors at Yale Bulldogs | 24 - 41 | Yale Bowl |
| Sat Oct 3 | 12:00 PM ET | Brown Bears vs Rhode Island Rams | 10 - 13 | Centennial Bank Stadium neutral |
| Sat Oct 3 | 12:30 PM ET | Michigan State Spartans at Wisconsin Badgers | 3 - 31 | Camp Randall Stadium |
| Sat Oct 3 | 12:30 PM ET | Cornell Big Red at Georgetown Hoyas | 35 - 14 | Cooper Field |
| Sat Oct 3 | 12:30 PM ET | Richmond Spiders at Lafayette Leopards | 40 - 31 | Fisher Stadium |
| Sat Oct 3 | 12:45 PM ET | Vanderbilt Commodores at Georgia Bulldogs | 14 - 38 | Sanford Stadium |
| Sat Oct 3 | 1:00 PM ET | Western Michigan Broncos vs Buffalo Bulls | 20 - 17 | Kidd Brewer Stadium neutral |
| Sat Oct 3 | 1:00 PM ET | Morgan State Bears at Villanova Wildcats | 38 - 35 | Villanova Stadium |
| Sat Oct 3 | 1:00 PM ET | Dayton Flyers at Drake Bulldogs | 22 - 30 | Drake Stadium |
| Sat Oct 3 | 1:00 PM ET | Marist Red Foxes at Stetson Hatters | 28 - 14 | Spec Martin Stadium |
| Sat Oct 3 | 1:00 PM ET | Valparaiso Beacons at Morehead State Eagles | 37 - 3 | Jayne Stadium |
| Sat Oct 3 | 1:00 PM ET | Elon Phoenix vs New Hampshire Wildcats | 23 - 30 | Anthony Field at Wildcat Stadium neutral |
| Sat Oct 3 | 1:00 PM ET | Towson Tigers at Monmouth Hawks | 40 - 41 | Kessler Stadium |
| Sat Oct 3 | 1:30 PM ET | Pennsylvania Quakers vs Dartmouth Big Green | 10 - 14 | Alumni Memorial Field neutral |
| Sat Oct 3 | 1:30 PM ET | Mercer Bears vs VMI Keydets | 54 - 3 | Foster Pavilion neutral |
| Sat Oct 3 | 2:00 PM ET | Toledo Rockets at Ball State Cardinals | 39 - 24 | Scheumann Stadium |
| Sat Oct 3 | 2:00 PM ET | Murray State Racers at North Dakota Fighting Hawks | 28 - 55 | Alerus Center |
| Sat Oct 3 | 2:00 PM ET | Norfolk State Spartans at Robert Morris Colonials | 31 - 33 | Joe Walton Stadium |
| Sat Oct 3 | 2:00 PM ET | Wofford Terriers at Furman Paladins | 32 - 25 | Paladin Stadium |
| Sat Oct 3 | 2:00 PM ET | The Citadel Bulldogs at South Carolina State Bulldogs | 34 - 31 | Oliver C. Dawson Stadium |
| Sat Oct 3 | 3:00 PM ET | Howard Bison vs Hampton Pirates | 27 - 13 | Audi Field neutral |
| Sat Oct 3 | 3:00 PM ET | Indiana State Sycamores at South Dakota Coyotes | 14 - 44 | DakotaDome |
| Sat Oct 3 | 3:00 PM ET | Alcorn State Braves at Grambling Tigers | 59 - 63 | Eddie G. Robinson Memorial Stadium |
| Sat Oct 3 | 3:00 PM ET | Prairie View A&M Panthers at Mississippi Valley State Delta Devils | 27 - 28 | Rice-Totten Stadium |
| Sat Oct 3 | 3:30 PM ET | Florida Gators vs Missouri Tigers | 17 - 45 | Mississippi Veterans Memorial Stadium neutral |
| Sat Oct 3 | 3:30 PM ET | Auburn Tigers at Tennessee Volunteers | 14 - 24 | Neyland Stadium |
| Sat Oct 3 | 3:30 PM ET | Louisville Cardinals at NC State Wolfpack | 28 - 31 | Carter-Finley Stadium |
| Sat Oct 3 | 3:30 PM ET | Virginia Cavaliers at Florida State Seminoles | 7 - 38 | Doak Campbell Stadium |
| Sat Oct 3 | 3:30 PM ET | Ohio State Buckeyes at Iowa Hawkeyes | 31 - 14 | Kinnick Stadium |
| Sat Oct 3 | 3:30 PM ET | Akron Zips at Central Michigan Chippewas | 17 - 41 | Kelly/Shorts Stadium |
| Sat Oct 3 | 3:30 PM ET | Eastern Michigan Eagles at UMass Minutemen | 38 - 14 | Warren McGuirk Alumni Stadium |
| Sat Oct 3 | 3:30 PM ET | Ohio Bobcats at Kent State Golden Flashes | 13 - 10 | Dix Stadium |
| Sat Oct 3 | 3:30 PM ET | Bowling Green Falcons at Miami (OH) Redhawks | 24 - 20 | Yager Stadium |
| Sat Oct 3 | 3:30 PM ET | Old Dominion Monarchs at Georgia State Panthers | 10 - 42 | Center Parc Stadium |
| Sat Oct 3 | 3:30 PM ET | California Golden Bears at UNLV Runnin' Rebels | 31 - 39 | Allegiant Stadium |
| Sat Oct 3 | 3:30 PM ET | Samford Bulldogs at UAB Blazers | 14 - 33 | Protective Stadium |
| Sat Oct 3 | 3:30 PM ET | Wyoming Cowboys at North Dakota State Bison | 0 - 28 | Fargo Dome |
| Sat Oct 3 | 3:30 PM ET | Sacred Heart Pioneers at Maine Black Bears | 24 - 16 | Alfond Stadium |
| Sat Oct 3 | 3:30 PM ET | Delaware State Hornets at UAlbany Great Danes | 3 - 28 | Bob Ford Field at Tom & Mary Casey Stadium |
| Sat Oct 3 | 3:30 PM ET | Holy Cross Crusaders at William & Mary Tribe | 41 - 14 | Zable Stadium |
| Sat Oct 3 | 3:30 PM ET | Chattanooga Mocs at East Tennessee State Buccaneers | 3 - 14 | William B. Greene Jr. Stadium |
| Sat Oct 3 | 3:45 PM ET | Marshall Thundering Herd at James Madison Dukes | 17 - 45 | Bridgeforth Stadium |
| Sat Oct 3 | 4:00 PM ET | Maryland Terrapins at Nebraska Cornhuskers | 23 - 48 | Memorial Stadium (Lincoln, NE) |
| Sat Oct 3 | 4:00 PM ET | UTEP Miners at New Mexico Lobos | 7 - 61 | University Stadium (Albuquerque, NM) |
| Sat Oct 3 | 4:00 PM ET | Northern Colorado Bears at Montana Grizzlies | 14 - 36 | Washington-Grizzly Stadium |
| Sat Oct 3 | 4:00 PM ET | Tennessee State Tigers at Western Illinois Leathernecks | 21 - 28 | Hanson Field |
| Sat Oct 3 | 4:00 PM ET | Davidson Wildcats at San Diego Toreros | 14 - 63 | Torero Stadium |
| Sat Oct 3 | 4:00 PM ET | Alabama State Hornets at Bethune-Cookman Wildcats | 10 - 16 | Daytona Stadium |
| Sat Oct 3 | 4:15 PM ET | Kentucky Wildcats at South Carolina Gamecocks | 35 - 34 | Williams-Brice Stadium |
| Sat Oct 3 | 4:15 PM ET | Purdue Boilermakers vs Illinois Fighting Illini | 24 - 17 | Christy Mathewson-Memorial Stadium neutral |
| Sat Oct 3 | 5:00 PM ET | Youngstown State Penguins at Southern Illinois Salukis | 28 - 16 | Saluki Stadium |
| Sat Oct 3 | 5:00 PM ET | New Haven Chargers vs Austin Peay Governors | 17 - 42 | Fortera Stadium neutral |
| Sat Oct 3 | 5:00 PM ET | Alabama A&M Bulldogs vs Jackson State Tigers | 28 - 31 | Ladd-Peebles Stadium neutral |
| Sat Oct 3 | 6:00 PM ET | Oregon State Beavers at Colorado State Rams | 56 - 26 | Canvas Stadium |
| Sat Oct 3 | 6:00 PM ET | Texas Southern Tigers vs Florida Atlantic Owls | 10 - 66 | L&N Federal Credit Union Stadium neutral |
| Sat Oct 3 | 6:00 PM ET | Campbell Fighting Camels at North Carolina Central Eagles | 38 - 31 | O'Kelly-Riddick Stadum |
| Sat Oct 3 | 6:00 PM ET | North Alabama Lions at Eastern Kentucky Colonels | 20 - 16 | Roy Kidd Stadium |
| Sat Oct 3 | 6:00 PM ET | Incarnate Word Cardinals at Stephen F. Austin Lumberjacks | 26 - 28 | Homer Bryce Stadium |
| Sat Oct 3 | 6:00 PM ET | North Carolina A&T Aggies at Bryant Bulldogs | 30 - 31 | Beirne Stadium |
| Sat Oct 3 | 6:00 PM ET | Gardner-Webb Runnin' Bulldogs at Charleston Southern Buccaneers | 12 - 10 | Buccaneer Field |
| Sat Oct 3 | 6:00 PM ET | Tennessee Tech Golden Eagles at Western Carolina Catamounts | 20 - 44 | Bob Waters Field at E. J. Whitmire Stadium |
| Sat Oct 3 | 7:00 PM ET | Arkansas Razorbacks at Texas A&M Aggies | 7 - 34 | Kyle Field |
| Sat Oct 3 | 7:00 PM ET | BYU Cougars at TCU Horned Frogs | 17 - 10 | Amon G. Carter Stadium |
| Sat Oct 3 | 7:00 PM ET | UTSA Roadrunners at Rice Owls | 16 - 14 | Rice Stadium |
| Sat Oct 3 | 7:00 PM ET | Georgia Southern Eagles at Coastal Carolina Chanticleers | 31 - 24 | Brooks Stadium |
| Sat Oct 3 | 7:00 PM ET | UL Monroe Warhawks at South Alabama Jaguars | 35 - 52 | Hancock Whitney Stadium |
| Sat Oct 3 | 7:00 PM ET | South Dakota State Jackrabbits at Illinois State Redbirds | 31 - 14 | Hancock Stadium |
| Sat Oct 3 | 7:00 PM ET | Arkansas-Pine Bluff Golden Lions at Southern Jaguars | 41 - 10 | A. W. Mumford Stadium |
| Sat Oct 3 | 7:00 PM ET | Northwestern State Demons at Lamar Cardinals | 14 - 42 | Provost Umphrey Stadium |
| Sat Oct 3 | 7:00 PM ET | Nicholls Colonels at Houston Christian Huskies | 2 - 16 | Husky Stadium |
| Sat Oct 3 | 7:00 PM ET | Colgate Raiders at Harvard Crimson | 17 - 20 | Harvard Stadium |
| Sat Oct 3 | 7:00 PM ET | UT Rio Grande Valley Vaqueros vs East Texas A&M Lions | 17 - 20 | Memorial Stadium (Stephenville, TX) neutral |
| Sat Oct 3 | 7:00 PM ET | Chicago State Cougars vs Tarleton State Texans | 21 - 56 | Bishop Schmitt Field neutral |
| Sat Oct 3 | 7:30 PM ET | Texas Tech Red Raiders at Colorado Buffaloes | 29 - 7 | Folsom Field |
| Sat Oct 3 | 7:30 PM ET | Miami Hurricanes at Clemson Tigers | 41 - 13 | Memorial Stadium (Clemson) |
| Sat Oct 3 | 7:30 PM ET | Washington Huskies at USC Trojans | 21 - 25 | Los Angeles Memorial Coliseum |
| Sat Oct 3 | 7:30 PM ET | Temple Owls at South Florida Bulls | 17 - 13 | Raymond James Stadium |
| Sat Oct 3 | 7:30 PM ET | Army Black Knights at Louisiana Tech Bulldogs | 29 - 31 | Joe Aillet Stadium |
| Sat Oct 3 | 7:30 PM ET | Utah State Aggies at Boise State Broncos | 18 - 37 | Albertsons Stadium |
| Sat Oct 3 | 7:45 PM ET | McNeese Cowboys at LSU Tigers | 14 - 63 | Tiger Stadium (Louisiana) |
| Sat Oct 3 | 8:00 PM ET | Arkansas State Red Wolves vs Louisiana Ragin' Cajuns | 20 - 23 | Tiger Stadium (Louisiana) neutral |
| Sat Oct 3 | 8:00 PM ET | Indiana Hoosiers at Rutgers Scarlet Knights | 47 - 15 | SHI Stadium |
| Sat Oct 3 | 8:00 PM ET | Weber State Wildcats at Cal Poly Mustangs | 42 - 34 | Alex G. Spanos Stadium |
| Sat Oct 3 | 8:00 PM ET | Northern Arizona Lumberjacks vs Idaho State Bengals | 38 - 31 | ICCU Arena neutral |
| Sat Oct 3 | 8:00 PM ET | Southern Utah Thunderbirds at Utah Tech Trailblazers | 46 - 33 | Greater Zion Stadium |
| Sat Oct 3 | 8:00 PM ET | West Florida Argonauts vs Abilene Christian Wildcats | 7 - 35 | Wildcat Stadium neutral |
| Sat Oct 3 | 9:30 PM ET | Fresno State Bulldogs at Washington State Cougars | 26 - 6 | Martin Stadium |
| Sat Oct 3 | 10:30 PM ET | Baylor Bears vs Arizona State Sun Devils | 55 - 19 | Blue Mountain College Arena neutral |
| Sat Oct 3 | 10:30 PM ET | Texas State Bobcats at San Diego State Aztecs | 29 - 31 | Snapdragon Stadium |
| Sat Oct 3 | 10:30 PM ET | Eastern Washington Eagles at UC Davis Aggies | 38 - 49 | UC Davis health Stadium |
| Sat Oct 3 | 11:00 PM ET | Cincinnati Bearcats vs Arizona Wildcats | 7 - 34 | Delaware Stadium neutral |
| Sat Oct 3 | 11:59 PM ET | San Jose State Spartans at Hawai'i Rainbow Warriors | 20 - 16 | Clarence T. C. Ching Athletics Complex |