| Tue Oct 13 | 7:00 PM ET | Delaware Blue Hens at Middle Tennessee Blue Raiders | 30 - 33 | Floyd Stadium |
| Tue Oct 13 | 8:00 PM ET | Florida International Panthers vs Jacksonville State Gamecocks | 24 - 27 | Bank of America Stadium neutral |
| Wed Oct 14 | 7:30 PM ET | Kennesaw State Owls at Missouri State Bears | 21 - 24 | Robert W. Plaster Stadium |
| Wed Oct 14 | 8:00 PM ET | Western Kentucky Hilltoppers at Sam Houston Bearkats | 16 - 3 | Bowers Stadium |
| Thu Oct 15 | 7:30 PM ET | East Carolina Pirates at UAB Blazers | 17 - 30 | Protective Stadium |
| Thu Oct 15 | 7:30 PM ET | Georgia Southern Eagles at Old Dominion Monarchs | 23 - 15 | S.B. Ballard Stadium |
| Thu Oct 15 | 8:00 PM ET | Colorado State Rams vs Texas State Bobcats | 27 - 66 | Shuford Stadium neutral |
| Fri Oct 16 | 7:00 PM ET | Columbia Lions vs Pennsylvania Quakers | 28 - 27 | Frank Erwin Center neutral |
| Fri Oct 16 | 7:30 PM ET | Memphis Tigers at Tulane Green Wave | 17 - 31 | Yulman Stadium |
| Fri Oct 16 | 8:00 PM ET | Washington Huskies at Purdue Boilermakers | 38 - 26 | Ross-Ade Stadium |
| Fri Oct 16 | 8:00 PM ET | Appalachian State Mountaineers at Coastal Carolina Chanticleers | 35 - 32 | Brooks Stadium |
| Sat Oct 17 | 12:00 PM ET | Mississippi State Bulldogs at LSU Tigers | 0 - 31 | Tiger Stadium (Louisiana) |
| Sat Oct 17 | 12:00 PM ET | Florida Gators at Texas Longhorns | 27 - 24 | Darrell K Royal-Texas Memorial Stadium |
| Sat Oct 17 | 12:00 PM ET | Cincinnati Bearcats at West Virginia Mountaineers | 42 - 45 | Milan Puskar Stadium |
| Sat Oct 17 | 12:00 PM ET | Kansas Jayhawks at Kansas State Wildcats | 24 - 35 | Bill Snyder Family Football Stadium |
| Sat Oct 17 | 12:00 PM ET | Charleston Southern Buccaneers at Clemson Tigers | 0 - 37 | Memorial Stadium (Clemson) |
| Sat Oct 17 | 12:00 PM ET | Pittsburgh Panthers at Boston College Eagles | 21 - 27 | Alumni Stadium |
| Sat Oct 17 | 12:00 PM ET | Virginia Cavaliers at SMU Mustangs | 13 - 23 | Gerald J. Ford Stadium |
| Sat Oct 17 | 12:00 PM ET | Ohio State Buckeyes at Indiana Hoosiers | 19 - 15 | Memorial Stadium (Bloomington, IN) |
| Sat Oct 17 | 12:00 PM ET | Northwestern Wildcats at Michigan State Spartans | 24 - 21 | Spartan Stadium |
| Sat Oct 17 | 12:00 PM ET | Ball State Cardinals at Bowling Green Falcons | 32 - 31 | Doyt Perry Stadium |
| Sat Oct 17 | 12:00 PM ET | Georgia State Panthers at James Madison Dukes | 22 - 49 | Bridgeforth Stadium |
| Sat Oct 17 | 12:00 PM ET | Florida Atlantic Owls at Army Black Knights | 24 - 56 | Michie Stadium |
| Sat Oct 17 | 12:00 PM ET | Rhode Island Rams at Yale Bulldogs | 41 - 23 | Yale Bowl |
| Sat Oct 17 | 12:00 PM ET | Central Connecticut Blue Devils at Mercyhurst Lakers | 43 - 40 | Saxon Stadium |
| Sat Oct 17 | 12:00 PM ET | New Haven Chargers vs Robert Morris Colonials | 26 - 15 | Joe Walton Stadium neutral |
| Sat Oct 17 | 12:00 PM ET | Duquesne Dukes at Stonehill Skyhawks | 14 - 7 | W.B. Mason Stadium |
| Sat Oct 17 | 12:00 PM ET | Hampton Pirates at Sacred Heart Pioneers | 21 - 35 | Campus Field |
| Sat Oct 17 | 12:00 PM ET | Brown Bears at Princeton Tigers | 10 - 16 | Powers Field at Princeton Stadium |
| Sat Oct 17 | 12:00 PM ET | Chicago State Cougars vs North Carolina A&T Aggies | 12 - 27 | Truist Stadium neutral |
| Sat Oct 17 | 12:30 PM ET | Rutgers Scarlet Knights at Maryland Terrapins | 37 - 30 | SECU Stadium |
| Sat Oct 17 | 1:00 PM ET | Charlotte 49ers at Temple Owls | 38 - 31 | Lincoln Financial Field |
| Sat Oct 17 | 1:00 PM ET | UMass Minutemen vs Buffalo Bulls | 18 - 25 | Bragg Memorial Stadium neutral |
| Sat Oct 17 | 1:00 PM ET | The Citadel Bulldogs at Texas A&M Aggies | 0 - 41 | Kyle Field |
| Sat Oct 17 | 1:00 PM ET | Merrimack Warriors vs Dartmouth Big Green | 21 - 27 | Alumni Memorial Field neutral |
| Sat Oct 17 | 1:00 PM ET | Georgetown Hoyas at Colgate Raiders | 27 - 17 | Crown Field at Andy Kerr Stadium |
| Sat Oct 17 | 1:00 PM ET | Dayton Flyers at Butler Bulldogs | 19 - 9 | Bud and Jackie Sellick Bowl |
| Sat Oct 17 | 1:00 PM ET | Marist Red Foxes at Drake Bulldogs | 27 - 22 | Drake Stadium |
| Sat Oct 17 | 1:00 PM ET | Bryant Bulldogs at Maine Black Bears | 17 - 14 | Alfond Stadium |
| Sat Oct 17 | 1:00 PM ET | Monmouth Hawks vs New Hampshire Wildcats | 42 - 21 | Anthony Field at Wildcat Stadium neutral |
| Sat Oct 17 | 1:00 PM ET | Holy Cross Crusaders at Harvard Crimson | 7 - 30 | Harvard Stadium |
| Sat Oct 17 | 1:00 PM ET | Morehead State Eagles at Davidson Wildcats | 31 - 34 | Richardson Stadium |
| Sat Oct 17 | 1:00 PM ET | McNeese Cowboys at Northwestern State Demons | 24 - 21 | Harry Turpin Stadium |
| Sat Oct 17 | 1:30 PM ET | Western Michigan Broncos at Central Michigan Chippewas | 21 - 14 | Kelly/Shorts Stadium |
| Sat Oct 17 | 1:30 PM ET | VMI Keydets at Wofford Terriers | 14 - 41 | Gibbs Stadium |
| Sat Oct 17 | 2:00 PM ET | Lehigh Mountain Hawks at Cornell Big Red | 38 - 48 | Schoellkopf Field |
| Sat Oct 17 | 2:00 PM ET | South Dakota State Jackrabbits at North Dakota Fighting Hawks | 10 - 21 | Alerus Center |
| Sat Oct 17 | 2:00 PM ET | Austin Peay Governors at West Georgia Wolves | 24 - 10 | University Stadium |
| Sat Oct 17 | 2:00 PM ET | Presbyterian Blue Hose at Stetson Hatters | 47 - 43 | Spec Martin Stadium |
| Sat Oct 17 | 2:00 PM ET | West Georgia Wolves vs West Florida Argonauts | 3 - 37 | Gainbridge Fieldhouse neutral |
| Sat Oct 17 | 2:30 PM ET | Eastern Kentucky Colonels at Tennessee Tech Golden Eagles | 20 - 49 | Tucker Stadium |
| Sat Oct 17 | 2:30 PM ET | UAlbany Great Danes at Stony Brook Seawolves | 48 - 31 | Kenneth P. LaValle Stadium |
| Sat Oct 17 | 3:00 PM ET | Lafayette Leopards at Bucknell Bison | 20 - 7 | Christy Mathewson-Memorial Stadium |
| Sat Oct 17 | 3:00 PM ET | Idaho Vandals at Montana Grizzlies | 42 - 35 | Washington-Grizzly Stadium |
| Sat Oct 17 | 3:00 PM ET | Idaho State Bengals vs Weber State Wildcats | 20 - 27 | Roy Stewart Stadium neutral |
| Sat Oct 17 | 3:00 PM ET | Western Illinois Leathernecks at Southeast Missouri Redhawks | 30 - 40 | Houck Stadium |
| Sat Oct 17 | 3:00 PM ET | Grambling Tigers at Alabama A&M Bulldogs | 31 - 61 | Louis Crews Stadium |
| Sat Oct 17 | 3:00 PM ET | Alabama State Hornets at Arkansas-Pine Bluff Golden Lions | 21 - 15 | Simmons Bank Field |
| Sat Oct 17 | 3:00 PM ET | Alcorn State Braves at Prairie View A&M Panthers | 38 - 41 | Panther Stadium at Blackshear Field |
| Sat Oct 17 | 3:00 PM ET | Bethune-Cookman Wildcats at Mississippi Valley State Delta Devils | 34 - 14 | Rice-Totten Stadium |
| Sat Oct 17 | 3:00 PM ET | Florida A&M Rattlers at Jackson State Tigers | 17 - 27 | Mississippi Veterans Memorial Stadium |
| Sat Oct 17 | 3:00 PM ET | Lindenwood Lions at Eastern Illinois Panthers | 20 - 13 | O'Brien Field |
| Sat Oct 17 | 3:00 PM ET | Gardner-Webb Runnin' Bulldogs at UT Martin Skyhawks | 6 - 17 | Graham Stadium |
| Sat Oct 17 | 3:30 PM ET | Auburn Tigers at Georgia Bulldogs | 27 - 24 | Sanford Stadium |
| Sat Oct 17 | 3:30 PM ET | Missouri Tigers at Ole Miss Rebels | 3 - 31 | Vaught-Hemingway Stadium |
| Sat Oct 17 | 3:30 PM ET | Alabama Crimson Tide at Tennessee Volunteers | 10 - 26 | Neyland Stadium |
| Sat Oct 17 | 3:30 PM ET | Arizona State Sun Devils vs Texas Tech Red Raiders | 25 - 53 | AT&T Stadium neutral |
| Sat Oct 17 | 3:30 PM ET | Georgia Tech Yellow Jackets at Virginia Tech Hokies | 24 - 34 | Lane Stadium |
| Sat Oct 17 | 3:30 PM ET | North Carolina Tar Heels at Duke Blue Devils | 24 - 20 | Wallace Wade Stadium |
| Sat Oct 17 | 3:30 PM ET | Penn State Nittany Lions at Michigan Wolverines | 18 - 21 | Michigan Stadium |
| Sat Oct 17 | 3:30 PM ET | Toledo Rockets at Eastern Michigan Eagles | 34 - 14 | Rynearson Stadium |
| Sat Oct 17 | 3:30 PM ET | Akron Zips at Miami (OH) Redhawks | 14 - 34 | Yager Stadium |
| Sat Oct 17 | 3:30 PM ET | Northern Illinois Huskies at Wyoming Cowboys | 23 - 41 | War Memorial Stadium (Laramie, WY) |
| Sat Oct 17 | 3:30 PM ET | UNLV Runnin' Rebels vs Air Force Falcons | 31 - 41 | Falcon Stadium neutral |
| Sat Oct 17 | 3:30 PM ET | Morehouse College Maroon Tigers vs Howard Bison | 17 - 31 | William B. Greene Jr. Stadium neutral |
| Sat Oct 17 | 3:30 PM ET | Villanova Wildcats at Fordham Rams | 38 - 17 | Coffey Field |
| Sat Oct 17 | 3:30 PM ET | Towson Tigers at Campbell Fighting Camels | 20 - 24 | Barker-Lane Stadium |
| Sat Oct 17 | 4:00 PM ET | Illinois State Redbirds at Southern Illinois Salukis | 35 - 14 | Saluki Stadium |
| Sat Oct 17 | 4:00 PM ET | Stephen F. Austin Lumberjacks at Nicholls Colonels | 56 - 0 | Manning Field at John L. Guidry Stadium |
| Sat Oct 17 | 4:00 PM ET | Valparaiso Beacons at San Diego Toreros | 13 - 38 | Torero Stadium |
| Sat Oct 17 | 4:30 PM ET | Tulsa Golden Hurricane at Rice Owls | 38 - 17 | Rice Stadium |
| Sat Oct 17 | 5:00 PM ET | Troy Trojans vs Louisiana Ragin' Cajuns | 6 - 33 | Louis Crews Stadium neutral |
| Sat Oct 17 | 5:00 PM ET | South Dakota Coyotes at Murray State Racers | 48 - 20 | Roy Stewart Stadium |
| Sat Oct 17 | 5:00 PM ET | Long Island University Sharks at Wagner Seahawks | 14 - 9 | Wagner College Stadium |
| Sat Oct 17 | 5:00 PM ET | Lamar Cardinals at SE Louisiana Lions | 31 - 34 | Strawberry Stadium |
| Sat Oct 17 | 6:00 PM ET | Washington State Cougars at Oregon State Beavers | 30 - 48 | Reser Stadium |
| Sat Oct 17 | 6:00 PM ET | Northern Iowa Panthers at Youngstown State Penguins | 22 - 35 | Stambaugh Stadium |
| Sat Oct 17 | 6:30 PM ET | Morgan State Bears at Tennessee State Tigers | 16 - 25 | Nissan Stadium |
| Sat Oct 17 | 7:00 PM ET | Arkansas Razorbacks at Vanderbilt Commodores | 31 - 21 | FirstBank Stadium |
| Sat Oct 17 | 7:00 PM ET | TCU Horned Frogs at Baylor Bears | 17 - 6 | McLane Stadium |
| Sat Oct 17 | 7:00 PM ET | Florida State Seminoles at Miami Hurricanes | 35 - 43 | Hard Rock Stadium |
| Sat Oct 17 | 7:00 PM ET | Kent State Golden Flashes at South Florida Bulls | 2 - 29 | Raymond James Stadium |
| Sat Oct 17 | 7:00 PM ET | Arkansas State Red Wolves at Southern Miss Golden Eagles | 23 - 13 | M. M. Roberts Stadium |
| Sat Oct 17 | 7:00 PM ET | Nevada Wolf Pack at North Dakota State Bison | 17 - 31 | Fargo Dome |
| Sat Oct 17 | 7:00 PM ET | Montana State Bobcats at Eastern Washington Eagles | 56 - 20 | Roos Field |
| Sat Oct 17 | 7:00 PM ET | Portland State Vikings at Northern Arizona Lumberjacks | 25 - 38 | Walkup Dome |
| Sat Oct 17 | 7:00 PM ET | Central Arkansas Bears vs Tarleton State Texans | 35 - 49 | Kenan Memorial Stadium neutral |
| Sat Oct 17 | 7:00 PM ET | UT Rio Grande Valley Vaqueros vs Incarnate Word Cardinals | 16 - 41 | Gayle and Tom Benson Stadium neutral |
| Sat Oct 17 | 7:00 PM ET | Mercer Bears at Samford Bulldogs | 31 - 21 | Seibert Stadium |
| Sat Oct 17 | 7:00 PM ET | East Texas A&M Lions at Houston Christian Huskies | 24 - 43 | Husky Stadium |
| Sat Oct 17 | 7:00 PM ET | Abilene Christian Wildcats at North Alabama Lions | 31 - 28 | Braly Municipal Stadium |
| Sat Oct 17 | 7:30 PM ET | Kentucky Wildcats vs Oklahoma Sooners | 21 - 13 | Memorial Stadium (Clemson) neutral |
| Sat Oct 17 | 7:30 PM ET | Notre Dame Fighting Irish at BYU Cougars | 24 - 28 | LaVell Edwards Stadium |
| Sat Oct 17 | 7:30 PM ET | Oklahoma State Cowboys vs Houston Cougars | 32 - 35 | TDECU Stadium neutral |
| Sat Oct 17 | 7:30 PM ET | Elon Phoenix at Stanford Cardinal | 7 - 34 | Stanford Stadium |
| Sat Oct 17 | 7:30 PM ET | Louisville Cardinals at Syracuse Orange | 34 - 26 | JMA Wireless Dome |
| Sat Oct 17 | 7:30 PM ET | Wisconsin Badgers at UCLA Bruins | 7 - 17 | Rose Bowl |
| Sat Oct 17 | 8:00 PM ET | Navy Midshipmen at UTSA Roadrunners | 34 - 38 | Alamodome |
| Sat Oct 17 | 8:00 PM ET | Louisiana Tech Bulldogs at UL Monroe Warhawks | 24 - 0 | JPS Field at Malone Stadium |
| Sat Oct 17 | 8:00 PM ET | Cal Poly Mustangs at Northern Colorado Bears | 18 - 28 | Nottingham Field |
| Sat Oct 17 | 8:00 PM ET | UC Davis Aggies at Southern Utah Thunderbirds | 17 - 38 | Eccles Coliseum |
| Sat Oct 17 | 9:00 PM ET | San Jose State Spartans at UTEP Miners | 24 - 11 | Sun Bowl |
| Sat Oct 17 | 10:00 PM ET | Ohio Bobcats at Sacramento State Hornets | 48 - 7 | Hornet Stadium |
| Sat Oct 17 | 10:15 PM ET | Utah Utes at Colorado Buffaloes | 27 - 24 | Folsom Field |
| Sat Oct 17 | 10:30 PM ET | Wake Forest Demon Deacons at California Golden Bears | 41 - 7 | California Memorial Stadium |
| Sat Oct 17 | 10:30 PM ET | New Mexico Lobos at Hawai'i Rainbow Warriors | 21 - 10 | Clarence T. C. Ching Athletics Complex |
| Sat Oct 17 | 10:30 PM ET | Fresno State Bulldogs at San Diego State Aztecs | 23 - 26 | Snapdragon Stadium |
| Sat Oct 17 | 11:00 PM ET | Nebraska Cornhuskers at Oregon Ducks | 14 - 17 | Autzen Stadium |