| Tue Oct 20 | 7:00 PM ET | Middle Tennessee Blue Raiders vs Florida International Panthers | 26 - 23 | The Pit neutral |
| Tue Oct 20 | 7:00 PM ET | Missouri State Bears at Delaware Blue Hens | 38 - 61 | Delaware Stadium |
| Tue Oct 20 | 7:30 PM ET | South Alabama Jaguars at Marshall Thundering Herd | 13 - 20 | Joan C. Edwards Stadium |
| Wed Oct 21 | 8:00 PM ET | New Mexico State Aggies at Sam Houston Bearkats | 30 - 24 | Bowers Stadium |
| Thu Oct 22 | 7:00 PM ET | James Madison Dukes at Appalachian State Mountaineers | 31 - 34 | Kidd Brewer Stadium |
| Thu Oct 22 | 7:00 PM ET | Liberty Flames at Kennesaw State Owls | 34 - 6 | Fifth Third Bank Stadium |
| Thu Oct 22 | 7:30 PM ET | East Carolina Pirates at Memphis Tigers | 34 - 41 | Simmons Bank Liberty Stadium |
| Fri Oct 23 | 5:00 PM ET | North Carolina Central Eagles vs Delaware State Hornets | — | Alumni Stadium neutral |
| Fri Oct 23 | 5:00 PM ET | North Carolina Central Eagles vs Delaware State Hornets | 31 - 12 | Alumni Stadium neutral |
| Fri Oct 23 | 7:00 PM ET | UMass Minutemen at UConn Huskies | 16 - 35 | Pratt & Whitney Stadium at Rentschier Field |
| Fri Oct 23 | 7:00 PM ET | Duke Blue Devils at Virginia Cavaliers | 19 - 16 | Scott Stadium |
| Fri Oct 23 | 7:00 PM ET | Yale Bulldogs vs Pennsylvania Quakers | 21 - 24 | Frank Erwin Center neutral |
| Fri Oct 23 | 7:00 PM ET | Yale Bulldogs vs Pennsylvania Quakers | — | Frank Erwin Center neutral |
| Fri Oct 23 | 8:30 PM ET | Army Black Knights at Tulsa Golden Hurricane | 38 - 35 | Skelly Field at H. A. Chapman Stadium |
| Fri Oct 23 | 9:00 PM ET | Air Force Falcons at Wyoming Cowboys | 14 - 28 | War Memorial Stadium (Laramie, WY) |
| Fri Oct 23 | 10:30 PM ET | NC State Wolfpack at Stanford Cardinal | 28 - 31 | Stanford Stadium |
| Sat Oct 24 | 12:00 PM ET | Texas Tech Red Raiders at Cincinnati Bearcats | 24 - 37 | Nippert Stadium |
| Sat Oct 24 | 12:00 PM ET | West Virginia Mountaineers at TCU Horned Frogs | 24 - 20 | Amon G. Carter Stadium |
| Sat Oct 24 | 12:00 PM ET | California Golden Bears at SMU Mustangs | 20 - 59 | Gerald J. Ford Stadium |
| Sat Oct 24 | 12:00 PM ET | Pittsburgh Panthers at Miami Hurricanes | 23 - 52 | Hard Rock Stadium |
| Sat Oct 24 | 12:00 PM ET | Indiana Hoosiers at Michigan Wolverines | 13 - 6 | Michigan Stadium |
| Sat Oct 24 | 12:00 PM ET | Rutgers Scarlet Knights at Northwestern Wildcats | 14 - 42 | Ryan Field |
| Sat Oct 24 | 12:00 PM ET | Rice Owls vs Florida Atlantic Owls | 49 - 51 | University Credit Union Center neutral |
| Sat Oct 24 | 12:00 PM ET | Western Michigan Broncos at Toledo Rockets | 38 - 45 | Glass Bowl |
| Sat Oct 24 | 12:00 PM ET | LSU Tigers at Auburn Tigers | 38 - 17 | Jordan-Hare Stadium |
| Sat Oct 24 | 12:00 PM ET | New Hampshire Wildcats at Merrimack Warriors | 17 - 24 | Duane Stadium |
| Sat Oct 24 | 12:00 PM ET | Cornell Big Red at Brown Bears | 31 - 38 | Richard Gouse Field at Brown Stadium |
| Sat Oct 24 | 12:00 PM ET | New Haven Chargers vs Central Connecticut Blue Devils | 20 - 42 | Arute Field neutral |
| Sat Oct 24 | 12:00 PM ET | Stonehill Skyhawks vs Long Island University Sharks | 18 - 14 | O'Shaughnessy Stadium neutral |
| Sat Oct 24 | 12:00 PM ET | St. Thomas - Minnesota Tommies at Marist Red Foxes | 35 - 13 | Tenney Stadium at Leonidoff Field |
| Sat Oct 24 | 12:00 PM ET | UAlbany Great Danes vs Rhode Island Rams | 38 - 21 | FirstBank Stadium neutral |
| Sat Oct 24 | 12:00 PM ET | Wagner Seahawks at Duquesne Dukes | 21 - 52 | Arthur J. Rooney Athletic Field |
| Sat Oct 24 | 12:00 PM ET | San Diego Toreros at Dayton Flyers | 32 - 37 | Welcome Stadium |
| Sat Oct 24 | 1:00 PM ET | Baylor Bears at Kansas Jayhawks | 24 - 25 | David Booth Kansas Memorial Stadium |
| Sat Oct 24 | 1:00 PM ET | Akron Zips at Kent State Golden Flashes | 20 - 35 | Dix Stadium |
| Sat Oct 24 | 1:00 PM ET | Miami (OH) Redhawks at Central Michigan Chippewas | 28 - 27 | Kelly/Shorts Stadium |
| Sat Oct 24 | 1:00 PM ET | Bucknell Bison at Holy Cross Crusaders | 3 - 34 | Fitton Field |
| Sat Oct 24 | 1:00 PM ET | Butler Bulldogs at Drake Bulldogs | 33 - 21 | Drake Stadium |
| Sat Oct 24 | 1:00 PM ET | Presbyterian Blue Hose at Valparaiso Beacons | 7 - 24 | Brown Field |
| Sat Oct 24 | 1:00 PM ET | Jackson State Tigers at Bethune-Cookman Wildcats | 21 - 24 | Daytona Stadium |
| Sat Oct 24 | 1:00 PM ET | Campbell Fighting Camels at Maine Black Bears | 35 - 6 | Alfond Stadium |
| Sat Oct 24 | 1:00 PM ET | Lafayette Leopards at Fordham Rams | 31 - 17 | Coffey Field |
| Sat Oct 24 | 1:30 PM ET | Dartmouth Big Green at Columbia Lions | 38 - 18 | Robert K. Kraft Field at Lawrence A. Wien Stadium |
| Sat Oct 24 | 1:30 PM ET | East Tennessee State Buccaneers vs VMI Keydets | 38 - 0 | Foster Pavilion neutral |
| Sat Oct 24 | 1:30 PM ET | Norfolk State Spartans at South Carolina State Bulldogs | 7 - 22 | Oliver C. Dawson Stadium |
| Sat Oct 24 | 2:00 PM ET | North Dakota Fighting Hawks at South Dakota Coyotes | 23 - 26 | DakotaDome |
| Sat Oct 24 | 2:00 PM ET | Northern Iowa Panthers at Southern Illinois Salukis | — | Saluki Stadium |
| Sat Oct 24 | 2:00 PM ET | Mercyhurst Lakers at Robert Morris Colonials | 14 - 28 | Joe Walton Stadium |
| Sat Oct 24 | 2:00 PM ET | Colgate Raiders at Richmond Spiders | 6 - 13 | E. Claiborne Robins Stadium |
| Sat Oct 24 | 2:00 PM ET | Tarleton State Texans at West Georgia Wolves | 49 - 6 | University Stadium |
| Sat Oct 24 | 2:00 PM ET | Stetson Hatters at Morehead State Eagles | 31 - 38 | Jayne Stadium |
| Sat Oct 24 | 2:00 PM ET | Samford Bulldogs at Furman Paladins | 13 - 6 | Paladin Stadium |
| Sat Oct 24 | 2:00 PM ET | Stony Brook Seawolves at Bryant Bulldogs | 27 - 17 | Beirne Stadium |
| Sat Oct 24 | 2:00 PM ET | Monmouth Hawks at Hampton Pirates | 49 - 13 | Armstrong Stadium |
| Sat Oct 24 | 2:00 PM ET | Tennessee Tech Golden Eagles at The Citadel Bulldogs | 28 - 13 | Johnson Hagood Stadium |
| Sat Oct 24 | 2:30 PM ET | Chattanooga Mocs at Western Carolina Catamounts | 41 - 18 | Bob Waters Field at E. J. Whitmire Stadium |
| Sat Oct 24 | 3:00 PM ET | Oregon Ducks vs Illinois Fighting Illini | 10 - 21 | Kenan Memorial Stadium neutral |
| Sat Oct 24 | 3:00 PM ET | Indiana State Sycamores at Illinois State Redbirds | 10 - 17 | Hancock Stadium |
| Sat Oct 24 | 3:00 PM ET | Howard Bison at Morgan State Bears | 26 - 20 | Hughes Stadium |
| Sat Oct 24 | 3:00 PM ET | Weber State Wildcats vs Montana State Bobcats | 33 - 38 | Bobcat Stadium neutral |
| Sat Oct 24 | 3:00 PM ET | West Florida Argonauts vs Eastern Kentucky Colonels | 13 - 16 | Roy Kidd Stadium neutral |
| Sat Oct 24 | 3:00 PM ET | Southeast Missouri Redhawks at Eastern Illinois Panthers | 20 - 10 | O'Brien Field |
| Sat Oct 24 | 3:00 PM ET | Arkansas-Pine Bluff Golden Lions at Florida A&M Rattlers | 31 - 28 | Bragg Memorial Stadium |
| Sat Oct 24 | 3:00 PM ET | Princeton Tigers at Harvard Crimson | 7 - 35 | Harvard Stadium |
| Sat Oct 24 | 3:00 PM ET | Murray State Racers at South Dakota State Jackrabbits | 9 - 42 | Dana J. Dykhouse Stadium |
| Sat Oct 24 | 3:00 PM ET | Nicholls Colonels at Northwestern State Demons | 31 - 27 | Harry Turpin Stadium |
| Sat Oct 24 | 3:00 PM ET | Southern Jaguars at Texas Southern Tigers | 21 - 24 | Shell Energy Stadium |
| Sat Oct 24 | 3:00 PM ET | Chicago State Cougars vs Lindenwood Lions | 9 - 44 | Harlen C. Hunter Stadium neutral |
| Sat Oct 24 | 3:30 PM ET | Texas A&M Aggies at Alabama Crimson Tide | 20 - 31 | Bryant-Denny Stadium |
| Sat Oct 24 | 3:30 PM ET | Oklahoma Sooners at Mississippi State Bulldogs | 23 - 15 | Davis Wade Stadium |
| Sat Oct 24 | 3:30 PM ET | Tennessee Volunteers at South Carolina Gamecocks | 24 - 27 | Williams-Brice Stadium |
| Sat Oct 24 | 3:30 PM ET | BYU Cougars vs UCF Knights | 31 - 39 | Acrisure Stadium neutral |
| Sat Oct 24 | 3:30 PM ET | Boston College Eagles at Georgia Tech Yellow Jackets | 49 - 27 | Bobby Dodd Stadium |
| Sat Oct 24 | 3:30 PM ET | Iowa Hawkeyes at Minnesota Golden Gophers | 10 - 13 | Huntington Bank Stadium |
| Sat Oct 24 | 3:30 PM ET | Michigan State Spartans at UCLA Bruins | 10 - 28 | Rose Bowl |
| Sat Oct 24 | 3:30 PM ET | Hawai'i Rainbow Warriors vs Northern Illinois Huskies | 56 - 21 | Husky Stadium neutral |
| Sat Oct 24 | 3:30 PM ET | Sacramento State Hornets at Ball State Cardinals | 17 - 34 | Scheumann Stadium |
| Sat Oct 24 | 3:30 PM ET | Bowling Green Falcons vs Buffalo Bulls | 24 - 31 | Lebron James Arena neutral |
| Sat Oct 24 | 3:30 PM ET | North Texas Mean Green at Navy Midshipmen | 49 - 39 | Navy-Marine Corps Memorial Stadium |
| Sat Oct 24 | 3:30 PM ET | Lehigh Mountain Hawks at Villanova Wildcats | 18 - 24 | Villanova Stadium |
| Sat Oct 24 | 3:30 PM ET | Charleston Southern Buccaneers at Tennessee State Tigers | 20 - 7 | Nissan Stadium |
| Sat Oct 24 | 3:30 PM ET | Georgetown Hoyas at William & Mary Tribe | 28 - 27 | Zable Stadium |
| Sat Oct 24 | 3:45 PM ET | Kansas State Wildcats vs Arizona State Sun Devils | 17 - 28 | Raymond James Stadium neutral |
| Sat Oct 24 | 4:00 PM ET | Eastern Michigan Eagles at Ohio Bobcats | 20 - 24 | Peden Stadium |
| Sat Oct 24 | 4:00 PM ET | UL Monroe Warhawks at Troy Trojans | 21 - 14 | Veterans Memorial Stadium |
| Sat Oct 24 | 4:00 PM ET | UT Martin Skyhawks at Western Illinois Leathernecks | 24 - 55 | Hanson Field |
| Sat Oct 24 | 4:00 PM ET | Houston Christian Huskies at Lamar Cardinals | 10 - 35 | Provost Umphrey Stadium |
| Sat Oct 24 | 5:00 PM ET | San Jose State Spartans at Nevada Wolf Pack | 13 - 28 | Mackay Stadium |
| Sat Oct 24 | 5:00 PM ET | Louisiana Ragin' Cajuns at Southern Miss Golden Eagles | 31 - 35 | M. M. Roberts Stadium |
| Sat Oct 24 | 5:00 PM ET | Old Dominion Monarchs at Louisiana Tech Bulldogs | 0 - 26 | Joe Aillet Stadium |
| Sat Oct 24 | 5:00 PM ET | Utah Tech Trailblazers at Cal Poly Mustangs | 43 - 26 | Alex G. Spanos Stadium |
| Sat Oct 24 | 5:00 PM ET | Southern Utah Thunderbirds at Idaho Vandals | 28 - 31 | Kibbie Dome |
| Sat Oct 24 | 5:00 PM ET | McNeese Cowboys at Incarnate Word Cardinals | 6 - 38 | Gayle and Tom Benson Stadium |
| Sat Oct 24 | 5:00 PM ET | UT Rio Grande Valley Vaqueros vs Central Arkansas Bears | 30 - 27 | Estes Stadium neutral |
| Sat Oct 24 | 6:00 PM ET | Boise State Broncos at Washington State Cougars | 31 - 10 | Martin Stadium |
| Sat Oct 24 | 6:00 PM ET | Portland State Vikings vs Idaho State Bengals | 8 - 38 | ICCU Arena neutral |
| Sat Oct 24 | 6:00 PM ET | SE Louisiana Lions at Stephen F. Austin Lumberjacks | 24 - 45 | Homer Bryce Stadium |
| Sat Oct 24 | 6:30 PM ET | San Diego State Aztecs at Colorado State Rams | 49 - 56 | Canvas Stadium |
| Sat Oct 24 | 7:00 PM ET | Colorado Buffaloes at Oklahoma State Cowboys | 24 - 57 | Boone Pickens |
| Sat Oct 24 | 7:00 PM ET | Virginia Tech Hokies at Clemson Tigers | 20 - 16 | Memorial Stadium (Clemson) |
| Sat Oct 24 | 7:00 PM ET | Georgia State Panthers at Arkansas State Red Wolves | 32 - 38 | Centennial Bank Stadium |
| Sat Oct 24 | 7:00 PM ET | Northern Colorado Bears at UC Davis Aggies | 6 - 33 | UC Davis health Stadium |
| Sat Oct 24 | 7:00 PM ET | Prairie View A&M Panthers vs East Texas A&M Lions | 30 - 19 | Texas A&M-Commerce Field House neutral |
| Sat Oct 24 | 7:00 PM ET | Austin Peay Governors at North Alabama Lions | 27 - 21 | Braly Municipal Stadium |
| Sat Oct 24 | 7:30 PM ET | Vanderbilt Commodores at Kentucky Wildcats | 17 - 34 | Kroger Field |
| Sat Oct 24 | 7:30 PM ET | Ole Miss Rebels at Texas Longhorns | 27 - 34 | Darrell K Royal-Texas Memorial Stadium |
| Sat Oct 24 | 7:30 PM ET | Iowa State Cyclones vs Arizona Wildcats | 3 - 39 | Xcel Energy Center neutral |
| Sat Oct 24 | 7:30 PM ET | Syracuse Orange vs North Carolina Tar Heels | 31 - 30 | Kenan Memorial Stadium neutral |
| Sat Oct 24 | 7:30 PM ET | USC Trojans at Wisconsin Badgers | 7 - 24 | Camp Randall Stadium |
| Sat Oct 24 | 7:30 PM ET | Utah State Aggies vs Texas State Bobcats | 17 - 20 | Braly Municipal Stadium neutral |
| Sat Oct 24 | 8:00 PM ET | UTSA Roadrunners at Tulane Green Wave | 42 - 19 | Yulman Stadium |
| Sat Oct 24 | 10:00 PM ET | North Dakota State Bison at New Mexico Lobos | 16 - 21 | University Stadium (Albuquerque, NM) |
| Sat Oct 24 | 10:15 PM ET | Houston Cougars at Utah Utes | 13 - 21 | Rice-Eccles Stadium |