Thu Sep 17, 8:15 PM ET · Prime Video · Highmark Stadium, Buffalo
Upcoming · Tue 8:15 PM
Detroit Lions
1-0 · 9-7 last season
Implied24.5
At
BUF -4.5 Total 53.5 Live line · DET +190 · BUF -230
Buffalo Bills
1-0 · 12-6 last season
Implied29.0
Line movement open Sep 15
BUF spread
-4.5 -4.5
no move
Total
53.5 53.5
no move
FanDuel
DET @ BUF: the angle lands Tue 8:15 PM
Lines, matchups, injuries and forecast below are live now.
Key matchups
DET skill positions vs BUF defenseQB
#6/32
14.9 fpa
RB
#29/32
26.3 fpa
WR
#9/32
28.7 fpa
TE
#3/32
9.3 fpa
BUF skill positions vs DET defenseQB
#30/32
21.6 fpa
RB
#10/32
21.4 fpa
WR
#32/32
41.4 fpa
TE
#28/32
16.7 fpa
Rank 32 allows the most fantasy points to the position (softest matchup), 1 the fewest. Ratings blend the 2025-26 regular season (with a last-8-games form tilt) into current-season data as games are played: current weight = games / (games + 4), so the new season takes over quickly.
Game script & scoring
Projected points (market implied)
DET24.5
BUF29.0
Offense profile
DETRank of 32BUF
27.9
#6
Pts / G
27.9
#4
263.4
#4
Pass yds / G
238.8
#11
123.9
#9
Rush yds / G
151.7
#3
63.3
#10
Plays / G
62.5
#15
57%
Pass rate
49%
1.9
Pass TD / G
1.8
1.3
Rush TD / G
1.6
2.2
Sacks taken / G
2.4
0.4
INT thrown / G
0.7
Defense profile
DETRank of 32BUF
24.7
#22
Pts allowed / G
22.4
#13
251.2
#26
Pass yds allowed
186.8
#1
114.1
#14
Rush yds allowed
129.2
#24
3.1
Sacks / G
1.9
0.9
INT / G
0.9
1.9
Pass TD allowed
1.3
0.9
Rush TD allowed
1.3
Rank 1 = best of 32 (offense: most; defense: fewest allowed). Basis: rolling window from 2025-09-15, 20 games per team.
Weather
At kickoff · 2026-09-17 20:00 local
No weather factor
Conditions
Patchy rain nearby
Temp
62°F
feels 64°
Wind
3 mph NNE
gusts 3 mph
Rain
30%
0.00 in
Humidity
94%
- Patchy rain nearby, 62F, wind 2 mph: no weather factor
WeatherAPI hourly forecast · Grass surface
Injuries
DET 8 listed- IR Isiah Pacheco RB Back Severe
- Out Giovanni Manu OT Knee Minimal
- Out Kerby Joseph FS Knee Minimal
- Quest. Christian Mahogany G Knee Minimal
- IR Brian Branch FS Achilles Minimal
- IR Cade Mays C Wrist Minimal
- IR Damone Clark LB Undisclosed Minimal
- IR Payton Turner DE Unknown Minimal
BUF 6 listed- Out Ty Johnson RB Hamstring Severe
- Out Tyrell Shavers WR Unknown Severe
- Out Michael Danna OLB Unknown Minimal
- Out T.J. Sanders DE Knee Minimal
- Quest. Jedrick Wills OT Unknown Minimal
- IR Zane Durant DT Unknown Minimal
Trends & head-to-head
DET last 5W 31-30 vs NOW 19-16 @ CHIL 10-23 @ MINL 24-29 vs PITL 34-41 @ LA
BUF last 5W 36-31 @ HOUL 30-33 @ DENW 27-24 @ JAXW 35-8 vs NYJL 12-13 vs PHI
Head-to-head
- Dec 15, 2024 BUF 48 at DET 42
- Nov 24, 2022 BUF 28 at DET 25
Week 2 slate
Swipe for all 16 games this week.
DET @ BUF
Thu 8:15 PM ET
BUF -4.5
O/U 53.5
Unlocks Tue 8:15 PM
CAR @ ATL
Sun 1:00 PM ET
CAR -1.5
O/U 43.5
Unlocks Fri 1:00 PM
CIN @ HOU
Sun 1:00 PM ET
HOU -3
O/U 46.5
Unlocks Fri 1:00 PM
CLE @ TB
Sun 1:00 PM ET
TB -8.5
O/U 40.5
Unlocks Fri 1:00 PM
GB @ NYJ
Sun 1:00 PM ET
GB -3.5
O/U 44.5
Unlocks Fri 1:00 PM
MIN @ CHI
Sun 1:00 PM ET
CHI -5.5
O/U 49.5
Unlocks Fri 1:00 PM
NO @ BAL
Sun 1:00 PM ET
BAL -8.5
O/U 47.5
Unlocks Fri 1:00 PM
PHI @ TEN
Sun 1:00 PM ET
PHI -7
O/U 39.5
Unlocks Fri 1:00 PM
PIT @ NE
Sun 1:00 PM ET
NE -4.5
O/U 42.5
Unlocks Fri 1:00 PM
JAX @ DEN
Sun 4:05 PM ET
DEN -2.5
O/U 44.5
Unlocks Fri 4:05 PM
LV @ LAC
Sun 4:05 PM ET
LAC -7
O/U 43.5
Unlocks Fri 4:05 PM
MIA @ SF
Sun 4:25 PM ET
SF -13.5
O/U 45.5
Unlocks Fri 4:25 PM
SEA @ ARI
Sun 4:25 PM ET
SEA -4.5
O/U 41.5
Unlocks Fri 4:25 PM
WAS @ DAL
Sun 4:25 PM ET
DAL -3.5
O/U 50.5
Unlocks Fri 4:25 PM
IND @ KC
Sun 8:20 PM ET
KC -6.5
O/U 47.5
Unlocks Fri 8:20 PM
NYG @ LA
Mon 8:15 PM ET
LA -7.5
O/U 48.5
Unlocks Sat 8:15 PM