Sun Sep 27, 1:00 PM ET · FOX · Highmark Stadium, Buffalo Upcoming · Fri 1:00 PM
Los Angeles Chargers
0-2 · 8-9 last season
Implied21.5
At BUF -7.5 Total 50.5 Live line · LAC +300 · BUF -375
Buffalo Bills
2-0 · 12-6 last season
Implied29.0
Line movement open Sep 22 BUF spread -7 -7.5 0.5 Total 50.5 50.5 no move FanDuel

LAC @ BUF: the angle lands Fri 1:00 PM

Lines, matchups, injuries and forecast below are live now.

Key matchups

TeamPlayerPos ProjDK $ vs defenseFPAEdge
LAC Justin Herbert QB 17.4 $5,800 BUF #18 of 32 17.9 Neutral
LAC Omarion Hampton RB 13.7 $6,800 BUF #29 of 32 26.3 Smash
LAC Ladd McConkey WR 11.8 $5,900 BUF #18 of 32 31.9 Neutral
LAC Oronde Gadsden II TE 10.4 $3,500 BUF #4 of 32 10.6 Tough
BUF Josh Allen QB 24.8 $8,000 LAC #7 of 32 15.3 Tough
BUF James Cook III RB 17.8 $6,900 LAC #2 of 32 17.8 Tough
BUF Dalton Kincaid TE 11.6 $5,500 LAC #14 of 32 12.4 Neutral
BUF DJ Moore WR 9.9 $5,800 LAC #19 of 32 32.4 Neutral
LAC skill positions vs BUF defense
QB
#18/32
17.9 fpa
Average
RB
#29/32
26.3 fpa
Elite
WR
#18/32
31.9 fpa
Average
TE
#4/32
10.6 fpa
Avoid
BUF skill positions vs LAC defense
QB
#7/32
15.3 fpa
Avoid
RB
#2/32
17.8 fpa
Avoid
WR
#19/32
32.4 fpa
Good
TE
#14/32
12.4 fpa
Bad

Rank 32 allows the most fantasy points to the position (softest matchup), 1 the fewest. Ratings blend the 2025-26 regular season (with a last-8-games form tilt) into current-season data as games are played: current weight = games / (games + 4), so the new season takes over quickly.

Game script & scoring

Projected points (market implied)
LAC21.5
BUF29.0
Offense profile
LACRank of 32BUF
19.4 #27 Pts / G 28.5 #2
215.1 #19 Pass yds / G 240.7 #12
122.6 #10 Rush yds / G 154.2 #3
62.9 #13 Plays / G 63.2 #11
54% Pass rate 48%
1.3 Pass TD / G 1.8
0.6 Rush TD / G 1.7
3.6 Sacks taken / G 2.4
0.9 INT thrown / G 0.7
Defense profile
LACRank of 32BUF
21.1 #10 Pts allowed / G 22.9 #16
207.4 #9 Pass yds allowed 196.9 #5
107.4 #9 Rush yds allowed 125.6 #21
2.7 Sacks / G 2.1
1.1 INT / G 0.8
1.1 Pass TD allowed 1.4
0.9 Rush TD allowed 1.2

Rank 1 = best of 32 (offense: most; defense: fewest allowed). Basis: rolling window from 2025-09-23, 20 games per team.

Weather

Kickoff forecast posts within 3 days of kickoff. (Highmark Stadium, Buffalo)

DFS

LAC projected players
PosPlayerProj Floor / ceilDK $Val FD $vs
QB Justin Herbert 17.4 0.0 / 0.0 $5,800 3.01x $7,200 #18
RB Omarion Hampton 13.7 0.0 / 0.0 $6,800 2.01x $7,200 #29
WR Ladd McConkey 11.8 0.0 / 0.0 $5,900 2.01x $6,300 #18
TE Oronde Gadsden II 10.4 0.0 / 0.0 $3,500 2.98x $5,000 #4
WR Quentin Johnston 9.6 0.0 / 0.0 $4,900 1.95x $5,600 #18
WR Tre' Harris 8.4 0.0 / 0.0 $3,900 2.15x $4,900 #18
RB Keaton Mitchell 6.0 0.0 / 0.0 $4,300 1.39x $4,700 #29
BUF projected players
PosPlayerProj Floor / ceilDK $Val FD $vs
QB Josh Allen 24.8 0.0 / 0.0 $8,000 3.10x $9,100 #7
RB James Cook III 17.8 0.0 / 0.0 $6,900 2.57x $8,100 #2
TE Dalton Kincaid 11.6 0.0 / 0.0 $5,500 2.11x $5,700 #14
WR DJ Moore questionable 9.9 0.0 / 0.0 $5,800 1.71x $6,700 #19
WR Khalil Shakir 9.3 0.0 / 0.0 $4,800 1.95x $5,900 #19
WR Keon Coleman 6.9 0.0 / 0.0 $4,300 1.60x $5,400 #19
TE Dawson Knox 4.2 0.0 / 0.0 $2,800 1.51x $4,700 #14

Val = projected points per $1,000 of DraftKings salary. vs = the opposing defense's rank against that position (32 softest).

Build this slate in the optimizer See player props

Props

PlayerMarketLine ProjOverBookOpp rank
Josh Allen QB BUF Pass TD 1.5 1.6 -148 FanDuel #3
Josh Allen QB BUF Pass yds 242.5 225.5 -112 DraftKings #9
Josh Allen QB BUF Rush yds 35.5 36.8 -109 DraftKings #9
James Cook III RB BUF Rush yds 81.5 94.9 -114 DraftKings #9
Justin Herbert QB LAC Pass TD 1.5 1.4 +140 Bovada #12
Justin Herbert QB LAC Pass yds 219.5 213.5 -113 DraftKings #5
Justin Herbert QB LAC Rush yds 19.5 32.2 -105 Fanatics #21
Omarion Hampton RB LAC Rush yds 59.5 56.7 -110 DraftKings #21
Omarion Hampton RB LAC Receptions 1.5 2.6 -139 BetRivers #5
Omarion Hampton RB LAC Rec yds 11.5 14.7 -110 BetRivers #5
Ladd McConkey WR LAC Receptions 4.5 3.9 +123 BetRivers #5
Ladd McConkey WR LAC Rec yds 51.5 48.9 -114 DraftKings #5
DJ Moore WR BUF Receptions 3.5 2.7 -140 FanDuel #9
DJ Moore WR BUF Rec yds 49.5 38.2 -114 DraftKings #9

Best available over price per line. Opp rank = the defense's rank in that stat allowed (32 allows the most).

All LAC and BUF props with AI grades

Injuries

LAC 8 listed
  • Out Charlie Kolar TE Forearm Severe
  • Out David Njoku TE Forearm Severe
  • Out Deane Leonard CB Unknown Minimal
  • Out Elijah Molden FS Unknown Minimal
  • Out Isaiah World OT Unknown Minimal
  • Out Trey Pipkins III T Unknown Minimal
  • Quest. Dalvin Tomlinson DT Hamstring Minimal
  • Quest. Derwin James FS Hand Minimal
BUF 6 listed
  • Out Ty Johnson RB Unknown Severe
  • Out Tyrell Shavers WR Unknown Severe
  • Out Ed Oliver DT Unknown Minimal
  • Out T.J. Sanders DE Unknown Minimal
  • Quest. DJ Moore WR Unknown Minimal
  • IR Zane Durant DT Unknown Minimal
Full NFL injury report

Week 3 slate

Swipe for all 16 games this week.
ATL @ GB
Thu 8:15 PM ET
GB -5.5
O/U 43.5
Ready
CAR @ CLE
Sun 1:00 PM ET
CAR -2.5
O/U 41.5
Unlocks Fri 1:00 PM
CIN @ PIT
Sun 1:00 PM ET
CIN -3.5
O/U 42.5
Unlocks Fri 1:00 PM
HOU @ IND
Sun 1:00 PM ET
HOU -2.5
O/U 42.5
Unlocks Fri 1:00 PM
KC @ MIA
Sun 1:00 PM ET
KC -10.5
O/U 45.5
Unlocks Fri 1:00 PM
LAC @ BUF
Sun 1:00 PM ET
BUF -7.5
O/U 50.5
Unlocks Fri 1:00 PM
NE @ JAX
Sun 1:00 PM ET
JAX -2.5
O/U 45.5
Unlocks Fri 1:00 PM
NYJ @ DET
Sun 1:00 PM ET
DET -6.5
O/U 47.5
Unlocks Fri 1:00 PM
SEA @ WAS
Sun 1:00 PM ET
SEA -6.5
O/U 40.5
Unlocks Fri 1:00 PM
TEN @ NYG
Sun 1:00 PM ET
NYG -2.5
O/U 39.5
Unlocks Fri 1:00 PM
ARI @ SF
Sun 4:05 PM ET
SF -8.5
O/U 47.5
Unlocks Fri 4:05 PM
MIN @ TB
Sun 4:05 PM ET
MIN -1.5
O/U 42.5
Unlocks Fri 4:05 PM
BAL @ DAL
Sun 4:25 PM ET
BAL -3.5
O/U 52.5
Unlocks Fri 4:25 PM
LV @ NO
Sun 4:25 PM ET
NO -3
O/U 43.5
Unlocks Fri 4:25 PM
LA @ DEN
Sun 8:20 PM ET
LA -2.5
O/U 45.5
Unlocks Fri 8:20 PM
PHI @ CHI
Mon 8:15 PM ET
PHI -4.5
O/U 41.5
Unlocks Sat 8:15 PM
Updated Sep 23, 10:36 AM ET For entertainment and informational purposes only; not betting or gambling advice.