Sun Oct 4, 4:25 PM ET · CBS · Levi's Stadium, San Francisco Upcoming · Fri 4:25 PM

Denver Broncos

2-1 · 16-3 last season

Implied22.0

At SF -2.5 Total 46.5 Live line · DEN +120 · SF -142

San Francisco 49ers

3-0 · 13-5 last season

Implied24.5

Line movement open Sep 29 SF spread -2.5 -2.5 no move Total 46.5 46.5 no move FanDuel

DEN @ SF: the angle lands Fri 4:25 PM

Lines, matchups, injuries and forecast below are live now.

Key matchups

Team	Player	Pos	Proj	DK $	vs defense	FPA	Edge
DEN	Bo Nix	QB	16.3	$5,600	SF #12 of 32	16.8	Neutral
DEN	Jaylen Waddle	WR	14.3	$6,200	SF #15 of 32	30.6	Neutral
DEN	RJ Harvey	RB	9.9	$5,000	SF #21 of 32	23.3	Favorable
DEN	Evan Engram	TE	6.0	$2,900	SF #21 of 32	14.1	Favorable

DEN skill positions vs SF defense

#12/32

16.8 fpa

Bad

#21/32

23.3 fpa

Good

#15/32

30.6 fpa

Average

#21/32

14.1 fpa

Good

SF skill positions vs DEN defense

#11/32

16.6 fpa

Bad

#20/32

22.3 fpa

Good

#6/32

27.9 fpa

Avoid

#23/32

14.7 fpa

Good

Rank 32 allows the most fantasy points to the position (softest matchup), 1 the fewest. Ratings blend the 2025-26 regular season (with a last-8-games form tilt) into current-season data as games are played: current weight = games / (games + 4), so the new season takes over quickly.

Game script & scoring

Projected points (market implied)

DEN22.0

SF24.5

Offense profile

DENRank of 32SF

22.8 #14 Pts / G 26.9 #7

232.3 #16 Pass yds / G 244.2 #9

106.5 #24 Rush yds / G 114.3 #18

63.7 #7 Plays / G 61.0 #17

58% Pass rate 53%

1.5 Pass TD / G 2.1

0.9 Rush TD / G 1.1

1.5 Sacks taken / G 1.3

0.7 INT thrown / G 0.8

Defense profile

DENRank of 32SF

18.8 #4 Pts allowed / G 22.6 #16

211.4 #10 Pass yds allowed 242.6 #21

103.1 #7 Rush yds allowed 111.3 #13

3.8 Sacks / G 1.3

0.8 INT / G 0.4

1.2 Pass TD allowed 1.6

0.7 Rush TD allowed 0.9

Rank 1 = best of 32 (offense: most; defense: fewest allowed). Basis: rolling window from 2025-09-29, 20 games per team.

Weather

Kickoff forecast posts within 3 days of kickoff. (Levi's Stadium, San Francisco)

DFS

DEN projected players

Pos	Player	Proj	Floor / ceil	DK $	Val	FD $	vs
QB	Bo Nix	16.3	10.2 / 24.2	$5,600	2.91x	$7,600	#12
WR	Jaylen Waddle	14.3	7.2 / 24.5	$6,200	2.31x	$6,600	#15
RB	RJ Harvey	9.9	4.8 / 15.6	$5,000	1.97x	$5,800	#21
WR	Courtland Sutton	9.9	3.9 / 17.1	$4,900	2.02x	$6,000	#15
RB	J.K. Dobbins	9.4	4.6 / 17.2	$5,300	1.78x	$6,300	#21
WR	Pat Bryant	6.9	2.7 / 13.5	$4,200	1.65x	$5,300	#15
TE	Evan Engram	6.0	2.3 / 12.0	$2,900	2.06x	$5,000	#21